Brenda Hogue

Brenda.Hogue@asu.edu

480-965-9478

Biodesign Institute

A320D

TEMPE

School of Life Sciences

Professor

Faculty

TEMPE Campus

Mailcode

7501

Bio
Research
Teaching
Public Work

Biography

Brenda Hogue is a virologist who studies how coronaviruses, a large family of RNA viruses, that includes severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), assemble at intracellular membranes and their interplay with host cells that ultimately results in disease.

Professor Hogue and her team use state-of-the-art molecular approaches, virus reverse genetic systems and bioimaging, including confocal microscopy, cryo-electron microscopy (-EM) and X-ray free electron lasers (XFELs), to address structure/function and mechanistic questions about how coronaviruses assemble their proteins and RNA genome to form infectious particles. The lab studies a class of proteins known as viroporins. Ongoing research is directed at understanding the role of coronavirus viroporins in virus assembly and their contribution to development of inflammation during infection. The overall goal is to use information gained from the research to identify targets and use structure-based design for therapeutic and vaccine development.

CV

Hogue NIH Biosketch 2017.pdf

Education

Postdoctoral, UCLA School of Medicine
PhD University of Tennessee, Knoxville
MEd Duke University

https://biodesign.asu.edu/brenda-hogue

Research Interests

A major focus of the Hogue Lab research is directed toward understanding the molecular details of assembly and release of enveloped RNA viruses, using coronaviruses (CoV) as the major model. The lab focuses to a large extent on structure-function studies. CoVs acquire their envelope at the endoplasmic reticulum Golgi intermediate compartment (ERGIC) and are released through interplay with the cellular secretory pathway. Interactions between viral and cellular proteins are explored, the use of vesicular trafficking and assembly at ERGIC membranes are studied. A combination of genetic, biochemical, structural and imaging approaches is used to understand functions of the viral structural proteins. The lab's research uses of state-of-the-art confocal microscopy of fixed and live cells, cryo-electron microscopy (-EM), correlative light electron microscopy (CLEM), free electron lasers (XFELS), ion channel analysis, proteomics, reverse genetic manipulation of infectious genomic clones to study the viral proteins, their subcellular localization, transport within cells during assembly of wild-type and genetically altered VLPs and viruses and structural studies of both viruses and proteins. The lab is involved in a number of cross-disciplinary collaborations. We collaborate with engineers to study ion channel activity of CoV proteins that are important for virus assembly. Single particle analysis and structural studies with nanocrystals are being done at the XFEL facility, Linac Coherent Light Source, (LCLS), at Stanford University and the European XFEL that recently opened in Germany. XFELs produces ultrafast pulses of X-rays millions of times brighter than even the most powerful synchrotron sources. We are helping develop the technology for three-dimensional structure at atomic resolution of viruses and viral proteins, as well as future planning for time-resolved studies with these. The laboratory is also working on determining the structures of several coronavirus envelope proteins using the relatively new technology, crystallization in lipid cubic phase (LCP). We are particularly interested in a family of proteins known as viroporins. Many medically important viruses, including coronaviruses, encode and express viroporins. We are studying the role of coronavirus viroporins in virus assembly and also their role in development of inflammation during infection.

Publications

Hosseinizadeh, A. Mashayekhi, G., Copperman, J. Schwander, P., Dashti, A., Sepehr, R., Fung. R., Schmidt, M., Yoon, C.H., Hogue, B.G., Williams, G.J., Aquila, A., Ourmazd, A. 2017. Conformational landscape of a virus by single-particle X-ray scattering. Nat Methods Sep;14(9):877-881. doi: 10.1038/nmeth.4395. Epub 2017 Aug 14. PMID: 28805793.
Li X., Chiu C.Y., Wang H.J., Kassemeyer S., Botha S., Shoeman R.L., Lawrence R.M., Kupitz C., Kirian R., James D., Wang D., Nelson G., Messerschmidt M., Boutet S., Williams G.J., Hartmann E., Jafarpour A., Foucar L.M., Barty A., Chapman H., Liang M., Menzel A., Wang F., Basu S., Fromme R., Doak R.B., Fromme P., Weierstall U., Huang M.H., Spence J.C., Schlichting I., Hogue B.G., Liu H. 2017. Diffraction data of core-shell nanoparticles from an X-ray free electron laser. Nature Sci. Data 4:170048. PMID: 28398334.
Reddy H.K.N., Yoon C.H., Aquila A., Awel S., Ayyer K., Barty A., Berntsen P., Bielecki J., Bobkov S., Bucher M., Carini G.A., Carron S., Chapman H., Daurer B., DeMirci H., Ekeberg T., Fromme P., Hajdu J., Hanke M.F., Hart P., Hogue B.G., Hosseinizadeh A., Kim Y., Kirian R.A., Kurta R.P., Larsson D.S.D., Duane Loh N.., Maia F.R.N.C., Mancuso A.P., Mühlig K., Munke A., Nam D., Nettelblad C., Ourmazd A., Rose M., Schwander P., Seibert M., Sellberg J.A., Song C., Spence J.C.H., Svenda M., Van der Schot G., Vartanyants I.A., Williams G.J., Xavier P.L. 2017. Coherent soft X-ray diffraction imaging of coliphage PR772 at the Linac coherent light source.
Deb A, Johnson WA, Kline AP, Scott BJ, Meador LR, Srinivas D, Martin-Garcia JM, Dörner K, Borges CR, Misra R, Hogue BG, Fromme P, Mor TS. 2017. Bacterial expression, correct membrane targeting and functional folding of the HIV-1membrane protein Vpu using a periplasmic signal peptide. PLoS One 12(2):e0172529. doi: 10.1371/journal.pone.0172529. PMID: 28225803.
Lawrence, R.M., Zook, J.D., Hogue, B.G. Full inactivation of alphaviruses in single particle and crystallized forms. 2016. J. Virol. Methods 236: 237-244.
Ding, J., Lawrence, R.M., Jones, P.V., Hogue, B.G., Hayes, M.A. 2016. Concentration of Sindbis virus with optimized gradient insulator-based dielectrophoresis. Analyst PMID: 26878279. DOI: 10.1039/c5an02430g
Munke, A., Andreasson, J., Aquila, A., Awel, S., Ayyer, K., Barty, A., Bean, R.J., Berntsen, P., Bielecki, J., Boutet, S., Bucher, M., Chapman, H.N., Daurer, B.J., DeMirci, H., Elser, V., Fromme, P., Hajdu, J., Hantke, M.F., Higashiura, A., Hogue, B.G., Hosseinzadeh, A., Kim, Y., Kirian, R.A., Kumar, H., Lan, T.-Y., Larsoon, D.S.D., Liu, H., Loh, N.D., Maia, F.R.N.C., Mancuso, A.P., Muhlig, K., Nakagawa, A., Nam, D., Nelson, G., Nettelblad, C., Okamoto, K., Ourmazd, A., Rose, M., van der Schot, G., Schwander, P., Seibert, M.M., Sellberg, J.A., Sierra, R.G., Song, C., Svenda, M., Timneanu, N., Vartanyants, I.A., Westphal, D., Wiedorn, M.O., Williams, G.J., Xavier, P.L., Yoon, C.H., Zook, J. 2016. Coherent diffraction of single Rice Dwarf Virus particles using hard X-rays at the Linac Coherent Light Source. Nature Scientific Data ug 1;3:160064. doi: 10.1038/sdata.2016.64
Kessans, S.A.f, Linhart, M., Meador, L.R., Kilbourne, J., Hogue, B.G., Fromme, P., Matoba, N., Mor, T.S. 2016. Immunological characterization of plant-based HIV-1 Gag/Dgp41 virus-like particles. PLOS One. 17;11(3):e0151842. doi: 10.1371/journal.pone.0151842. eCollection 2016. PMID:26986483
Stevenson, H., Lin, G., Barnes, C.O., Sutkeviciute, I., Krzysiak, T., Weiss, S.C., Reynolds, S., Wu, Y., Nagarajan, V., Makhov, A.M., Lawrence, R.a, Lamm, E., Clark, L., Gardella, T.J., Hogue, B.G., Ogata, C., Ahn, J., Gronenborn, A.M., Conway, J.F., Vilardaga, J.P., Cohen, A.E., and Calero, G. 2016. Transmission electron microscopy for the evaluation and optimization of crystal growth. Acta Crystallogr D Struct Biol. 72(Pt 5):603-615. Epub 2016 Apr 26. PMID:27139624.
Lawrence, R.M.a, Conrad, C.E., Grant, T.D., Zatsepin, N.A., Liu, H., James, D., Nelson, G., Subramanian, G., Aquila, A., Hunter, M.S., Liang, M., Boutet, S., Coe, J., Spence, J.C.H., Weierstall, U., Liu, W., Fromme, P., Cherezov, V., Hogue, B.G. 2015. Serial femtosecond X-ray diffraction of enveloped virus microcrystals. Struct. Dyn. 2, 041720; doi: 10.1063/1.4929410.
Venkatagopalan, P.b, Daskalova, S.M.a; Lopez, L.A.b, Dolezal, K.A.b and Hogue, B.G. 2015. Coronavirus envelope (E) protein remains at the site of assembly. Virology 478:75-85.
Gong Z, Kessans SA, Dörner K, Lee H-H, Meador LR, Hogue B.G., Mor TS, Fromme P. 2014. Recombinant expression, purification and biophysical characterization of the transmembrane and membrane proximal domains of HIV-1 gp41. Protein Sci 23:1607-1618.
Lee, H-H, Cherni, I, Yu, HQ, Fromme, R., Doran, J.D., Grotjohann, I., Basu, S., Dorner. K., Aquila, A., Barty, A., Boutet, S., Chapman, H.N., Doak, R.B., Hunter, M.S., James, D.R., Kirian, R.A., Kupitz, C., Lawrence, R.M.a, Liu, H., Nass, K., Schlichting, I., Schmidt, K.E., Seibert, M.M., Shoeman, R.L., Spence, J.C.H., Stellato, F., Weierstall,U., Williams, G.J., Yoon, CH, Wang, D., Zatsepin, N.A., Hogue, B.G., Matoba, N., Fromme, P. Mor T.S. Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1. International Union of Crystallography Journal doi:10.1107/S2052252514014900. pages 305 - 317 (2014).
Arndt, A.L., Larson, B.J. and Hogue, B.G. A conserved domain in the coronavirus membrane protein tail is important for virus assembly. Journal of Virology (2010).
Burk DR, Senechal-Willis P, Lopez LC, Hogue BG, Daskalova SM. Suppression of lipopolysaccharide-induced inflammatory responses in RAW 264.7 murine macrophages by aqueous extract of Clinopodium vulgare L. (Lamiaceae). J. Ethnopharmacol (2009).
Lisa Lopez, Ambere Riffle, Steven Pike, Douglas Gardner, Brenda Hogue. Functional requirement of conserved cysteine residues in the coronavirus envelope protein. Journal of Virology (2008).
Hogue, B.G. and Machamer, C.M. Coronavirus Structural Proteins and Assembly. The Nidoviruses (2008).
Hogue, Brenda, Machamer, C. Coronavirus Structural Proteins and Assembly. In The Nidoviruses. (2008).
S Verma, L Lopez, Valerie Bednar, Brenda Hogue. Importance of coronavirus membrane protein penultimate charged residue in virus assembly. Journal of Virology (2007).
T White, Z Yi, Brenda Hogue. Identification of mouse hepatitis coronavirus nucleocapsid protein phosphorylation sites. Virus Research (2007).
Y Ye, Brenda Hogue. Role of the Coronavirus E Viroporin Protein Transmembrane Domain in Virus Assembly. Journal of Virology (2007).
Y Ye, K Hauns, J Langland, B Jacobs, Brenda Hogue. Mouse Hepatitis Coronavirus A59 Nucleocapsid Protein is a Type I Interferon Antagonist. Journal of Virology (2007).
S Verma, V Bednar, A Blount, Brenda Hogue. Role of coronavirus nucleocapsid protein COOH terminal conserved amino acids in virus assembly. Journal of Virology (2006).
Bednar, V,Verma, S,Blount, A,Hogue, Brenda G. Importance of MHV-CoV nucleocapsid protein COOH-termina negative charges. The Nidoviruses : Toward the Control of SARS and Other Nidovirus Diseases (2006).
Lopez, L A (Author) ,Jones, A (Author) ,Arndt, W D (Author) ,Hogue, Brenda G (Corresponding Author) . Subcellular localization of SARS-CoV structural proteins. The Nidoviruses : The Control of SARS and other Nidovirus Diseases (2006).
White, T C (Author) ,Hogue, Brenda G (Corresponding Author) . Mouse hepatitis coronavirus nucleocapsid phosphorylation. The Nidoviruses : The Control of SARS and other Nidovirus Diseases (2006).
Ye, Y (Author) ,Hogue, Brenda G (Corresponding Author) . Role of mouse hepatitis coronavirus envelope protein transmembrane domain. The Nidoviruses : The Control of SARS and other Nidovirus Diseases (2006).
Spagnolo, J F (Author) ,Hogue, Brenda G (Author) . Requirement of the Poly(A) Tail in Coronavirus Genome Replication. The Nidoviruses (2001).
Jeannie Spagnolo, Brenda Hogue. Host protein interactions with the 3' end of bovine coronavirus RNA and the requirement of the poly(A) tail for coronavirus defective genome replication. J. Virol (2000).
R Cologna, Brenda Hogue. Identification of a bovine coronavirus packaging signal. J. Virol (2000).
R Cologna, J Spagnolo, Brenda Hogue. Identification of nucleocapsid binding sites within coronavirus defective genomes. Virology (2000).

Research Activity

Spence,John Charles*, Carpenter,Ray W, Frasch,Wayne D, Fromme,Petra, Halden,Rolf, Hogue,Brenda G, Labaer,Joshua, Leket-Mor,Tsafrir Shlomo, Liu,Jingyue, Liu,Wei, Mason,Hugh S, Muthuswamy,Jitendran, Olive,Michael Foster, Rege,Kaushal, Rez,Peter, Rittmann,Bruce Edward, Roberson,Robert Wayne, Ros,Alexandra, Ros,Robert, Stabenfeldt,Sarah E, Torres,Cesar I, Van Horn,Wade Dale, Vermaas,Willem F J, Wachter,Rebekka M, Weierstall,Uwe Juergen, Westerhoff,Paul, Wiktor,Peter Jan, Yan,Hao. MRI: Acquisition of Cryo-EM for Southwest Regional Center. NSF-BIO-DBI(9/1/2015 - 8/31/2018).
Hogue,Brenda G*, Fromme,Petra. YR 4: Carillo (Hogue) Supplement: Center for Membrane Proteins in Infectious Diseases (MPID). HHS-NIH-NIGMS(12/1/2013 - 6/30/2015).
Spence,John Charles*, Fromme,Petra, Greenes,Carole E., Greenes,Carole E., Hogue,Brenda G, Weierstall,Uwe Juergen. Biology with X-ray Lasers. STATE UNIV OF NY-BUFFALO(8/1/2013 - 9/30/2018).
Newfeld,Stuart J*, Francisco,Wilson Alex, Hogue,Brenda G, Rutowski,Ronald L. Graduate and Undergraduate Training in Biomedicine at ASU. HHS-NIH-NIGMS(3/2/2012 - 1/31/2016).
Hayes,Mark A*, Hogue,Brenda G. Isolating Viral Particles from Whole Blood. HHS-NIH-NIAID(2/7/2012 - 1/31/2015).
Hogue,Brenda G*. Arizona State University PREP for Biomedical Research. HHS-NIH-NIGMS(9/23/2011 - 7/31/2016).
Weierstall,Uwe Juergen*, Doak,R Bruce, Hogue,Brenda G, Schmidt,Kevin Edward, Spence,John Charles. EAGER Renewal: Femtosecond Virus Structure. NSF-BIO(8/1/2011 - 7/31/2014).
Fromme,Petra*, Allen,James Paul, Ghirlanda,Giovanna, Hogue,Brenda G, Johnston,Stephen Albert, Kumar,Sudhir, Labaer,Joshua, Leket-Mor,Tsafrir Shlomo, Ozkan,Sefika Banu, Sykes,Kathryn, Wachter,Rebekka M, Woodbury,Neal Walter. Center for Membrane Proteins in Infectious Diseases (MPID). HHS-NIH-NIGMS(7/1/2011 - 6/30/2016).
Duch,Carsten Juergen*, Chang,Yung, Hogue,Brenda G, Jung,Ranu, Kusumi,Kenro, Neisewander,Janet Leigh, Newfeld,Stuart J, Smith,Brian. Acquisition of a Leica TCS SP5 Laser Scanning Confocal Microscope. HHS-NIH-NCRR(5/1/2011 - 4/30/2012).
Fromme,Petra*, Allen,James Paul, Ghirlanda,Giovanna, Hogue,Brenda G, Kumar,Sudhir, Labaer,Joshua, Leket-Mor,Tsafrir Shlomo, Ozkan,Sefika Banu, Sykes,Kathryn, Wachter,Rebekka M, Woodbury,Neal Walter. YR 1: Center for Membrane Proteins in Infectious Diseases (MPID). HHS-NIH-NIGMS(9/30/2010 - 6/30/2012).
Weierstall,Uwe Juergen*, Doak,R Bruce, Hogue,Brenda G, Schmidt,Kevin Edward, Spence,John Charles. EAGER: Femtosecond Virus Structure. NSF-BBS-DMB(8/1/2009 - 7/31/2011).
Hogue,Brenda G*. Yr 5: Arizona State University PREP for Biomedical Research. HHS-NIH-NIGMS(9/1/2008 - 8/31/2011).
Hogue,Brenda G*, Huang,Zhong. Development of a plant derived virus like particle vaccine against SARS-CoV. HHS-NIH-NIAID(3/1/2008 - 2/28/2011).
Hogue,Brenda G*, Arndt,Ariel Louise. Role of Coronavirus Membrane Protein Carboxy Tail in Virus Assembly. HHS-NIH-NIAID(12/21/2007 - 12/19/2010).
Hogue,Brenda G*. Yr 4: Arizona State University PREP for Biomedical Research. HHS-NIH-NIGMS(9/1/2007 - 8/31/2009).
Hogue,Brenda G*. Kids Seek Cure for Kids. CHDRN HOSPITAL LA(4/1/2007 - 3/31/2008).
Hogue,Brenda G*. Yr 3: Arizona State University PREP for Biomedical Research. HHS-NIH(9/1/2006 - 8/31/2007).
Hogue,Brenda G*. Yr 1: Arizona State University PREP for Biomedical Research. HHS-NIH-NIGMS(9/25/2004 - 8/31/2009).
Hogue,Brenda G*. Yr 2: Arizona State University PREP for Biomedical Research. HHS-NIH(9/25/2004 - 8/31/2009).
Hogue,Brenda G*. Yr 2: Arizona State University PREP for Biomedical Research. HHS-NIH(9/24/2004 - 8/31/2009).
Hogue,Brenda G*. MOLECULAR ANALYSIS OF CORONAVIRUS ASSEMBLY. HHS-NIH-NIAID(9/15/2003 - 2/28/2010).
Hogue,Brenda G*. MOLECULAR ANALYSIS OF CORONAVIRUS ASSEMBLY-Continued in JKS0031. HHS-NIH-NIAID(9/15/2003 - 2/29/2008).

Courses

Fall 2019
Course Number	Course Title
MIC 485	General Virology
MIC 492	Honors Directed Study
BIO 492	Honors Directed Study
MIC 495	Undergraduate Research
MIC 598	Special Topics
MCB 598	Special Topics
BIO 598	Special Topics
BDE 792	Research

Summer 2019
Course Number	Course Title
MBB 495	Undergraduate Research

Spring 2019
Course Number	Course Title
MIC 493	Honors Thesis
BIO 493	Honors Thesis
MBB 495	Undergraduate Research
MIC 495	Undergraduate Research
BIO 598	Special Topics
BDE 792	Research

Fall 2018
Course Number	Course Title
MIC 485	General Virology
MIC 492	Honors Directed Study
BIO 492	Honors Directed Study
MIC 495	Undergraduate Research
MIC 598	Special Topics
MCB 598	Special Topics
BIO 598	Special Topics
BDE 792	Research

Summer 2018
Course Number	Course Title
MBB 495	Undergraduate Research

Spring 2018
Course Number	Course Title
MIC 493	Honors Thesis
BIO 493	Honors Thesis
MIC 495	Undergraduate Research
MBB 495	Undergraduate Research
BIO 598	Special Topics

Fall 2017
Course Number	Course Title
MIC 485	General Virology
MIC 492	Honors Directed Study
BIO 492	Honors Directed Study
MIC 495	Undergraduate Research
MIC 598	Special Topics
MCB 598	Special Topics
BIO 598	Special Topics
BDE 792	Research

Summer 2017
Course Number	Course Title
MBB 495	Undergraduate Research

Spring 2017
Course Number	Course Title
MIC 493	Honors Thesis
BIO 493	Honors Thesis
MIC 495	Undergraduate Research
MBB 495	Undergraduate Research
BIO 598	Special Topics

Fall 2016
Course Number	Course Title
BIO 189	Life Sciences Career Paths
MIC 485	General Virology
BIO 492	Honors Directed Study
MIC 492	Honors Directed Study
MIC 495	Undergraduate Research
MIC 598	Special Topics
MCB 598	Special Topics
BIO 598	Special Topics
BDE 792	Research

Summer 2016
Course Number	Course Title
MBB 495	Undergraduate Research

Spring 2016
Course Number	Course Title
MIC 495	Undergraduate Research
MBB 495	Undergraduate Research
BIO 598	Special Topics

Fall 2015
Course Number	Course Title
MIC 401	Research Paper
MIC 485	General Virology
MIC 495	Undergraduate Research
BIO 598	Special Topics
MCB 598	Special Topics
MIC 598	Special Topics
BDE 792	Research

Summer 2015
Course Number	Course Title
MBB 495	Undergraduate Research

Spring 2015
Course Number	Course Title
MIC 401	Research Paper
MIC 598	Special Topics
BIO 598	Special Topics
BDE 792	Research

Presentations

Lawrence, R.M., Liu, H., Kassemeyer, S., Botha, S., Wang. D., James, D.1, Fromme, P., Fromme, R., Weierstall, U., Spence, J.C., Schlichting, I., Hogue, B.G. Virus Single Particle Studies Using the XFEL. SSRL/LCLS Annual Users Meeting & Workshops (Oct 2014).
Lawrence, R.M., Basu, S., Liu, H., Roy-Chowdhury, S., James, D., Nelson, G., Fromme, P., U., Snell, E., Reddy, V., Hogue, B.G. XFEL Structural Analysis of Whole Virus and Viral Capsid Nanocrystals. SSRL/LCLS Annual Users Meeting & Workshops (Oct 2014).
Esqueda, A., Carrillo, J., Daskalova, S.M., Goryll, M. Hogue, B.G. Characterization of Coronavirus Small Envelope Protein (E) Ion Channel Activity and Its Role in Virus Assembly. 33rd American Society for Virology, Colorado State U., (Jul 2014).
Brenda G. Hogue. Coronavirus Envelope Ion Channel Activity: Is It Actually Required for Virus Assembly?. XIIIth International Nidovirus Symposium, Salamanca, Spain (Jun 2014).
Lawrence, R.M., Fromme, R., Fromme, P., Weierstall, U., Hogue, B.G. Biological Inactivation of Sindbis Virus Particles and Effects on Nanocrystal Formation. BioXFEL Science & Technology Center NSF Site Visit, Hauptman Woodward Medical Research Institute, Bu (Jun 2014).
Lawrence, R.M. Liu, H. Kassemeyer, S. Botha, S. Wang. D., James, D., Fromme, P.Fromme, R. Weierstall, U.Spence, J.C.1; Schlichting, Hogue, B.G. Progress Toward Virus Single Particle Studies Using the XFEL. BioXFEL Science & Technology Center NSF Site Visit, Hauptman Woodward Medical Research Institute, Bu (Jun 2014).
Brenda G. Hogue. Progress Toward Virus Structural Studies Using the Linac Coherent Light Source (LCLS). Arizona Science Center "Best of Phoenix" Lecture Series, Phoenix, AZ (May 2014).
Brenda G. Hogue. Coronavirus Assembly at Intracellular Membrane: Roles of the Membrane (M) and Envelope (E) Viroporin. Baylor College of Medicine Seminar (Apr 2014).
Brenda G. Hogue. Role of Coronavirus Envelope (E) Viroporins in Assembly at Intracellular Membranes. Keystone Symposium: The Ins and Outs of Viral Infection: Entry, Assembly, Exit and Spread (Mar 2014).
Carrillo, J., Esqueda, A., Daskalova, S.M., Goryll, M. Hogue, B.G. Coronavirus Small Envelope (E) Proteins: Ion Channel Characteristics and Role in Virus Assembly. Keystone Symposium: The Ins and Outs of Viral Infection: Entry, Assembly, Exit and Spread (Mar 2014).
Daskalova, S.M., Robida, M.D., Carrillo, J., Borges, C.R., Loskutov, A., Sykes, K.F., Fromme, P., Goryll, M. Hogue, B.G. Stategies for E. coli-based Expression and Purification of Coronavirus Envelope Proteins for Functional and Structural Studies. Frontiers of Structural Biology (Keystone Symposia on Molecular & Cellular Biology) (Mar 2014).
Lawrence, R.M., Blake, M. Fromme, R., Chen, L. Fromme, P. Weierstall, U. Hogue, B.G. Structural effects of virus particle inactivation for femtosecond x-ray laser studies. X-ray Lasers in Biology at The Royal Society, London (Oct 2013).
Lawrence, R.M., Blake, M. Fromme, R., Chen, L. Fromme, P. Weierstall, U. Hogue, B.G. Structural effects of virus particle inactivation for femtosecond x-ray laser studies. X-ray Lasers in Biology - techniques at The Royal Society at Chicheley Hall: Home of the Kavli Royal (Oct 2013).
Esqueda, A., Carrillo, J. Daskalova, S.M., Goryll, M., Hogue, B.G. Significance of coronavirus envelope (E) protein ion channel activity on virus assembly. American Society for Virology 32 Annual Meeting, Pennsylvania State University, University Park (Jul 2013).
Carrillo, J., Esqueda, A. Daskalova, S.M., Goryll, M. Hogue, B.G. Key amino acid residues of coronavirus envelope (E) proteins are important for ion channel activity. American Society for Virology 32 Annual Meeting, Pennsylvania State University, University Park (Jul 2013).
Pavithra Venkatagopalan, Sasha M. Daskalova, Raquel F. Epand, Richard M. Epand, Brenda G. Hogue. Insight into the Mechanistic Role of Coronavirus Envelope (E) Protein in Virus Assembly. American Society for Virology 31th Annual Meeting (Jul 2012).
Brenda G. Hogue. Dynamics of Coronavirus Assembly at ERGIC Membranes. University Indiana Bloomington, Department of Microbiology (Mar 2012).
Brenda G. Hogue. Coronavirus Assembly at Intracellular Membranes. University of Arizona Medical School Phoenix, Department of Basic Medical Sciences (Feb 2012).
Hogue, B.G. Coronaviruses and Arteriviruses. American Society for Virology 30th Annual Meeting (Jul 2011).
Venkatagopalan, R. Daskalova, S.M., Hogue, B.G. Role of the envelope protein during dynamics of coronavirus assembly. American Society for Virology 30th Annual Meeting (Jul 2011).
Arndt, A.L., Venkatagopalan, P., Larson, B.J., Daskalova, S.M. and Hogue, B.G. Roles of the Coronavirus Membrane in Virus Assembly. The Ninth International Symposium on Positive-Strand RNA Viruses (Jun 2011).
Venkatagopalan, P., Daskalova, S.M., Faulkner, L.D., Chaplot, N., Smolyanitsky, A., Goryll, M, and Hogue, B.G. Envelope (E) protein functions during coronavirus assembly. The Ninth International Symposium on Positive-Strand RNA Viruses (Jun 2011).
Arndt, A.L., Larson, B.J. and Hogue, B.G. Importance of Charged Residues in the Coronavirus Membrane Protein Tail. American Society for Virology 28th Annual Meeting (Jul 2010).
Kelly A. Dolezal, Sasha M. Daskalova, Brenda G. Hogue. Complementary functional domains in the coronavirus envelope protein. American Society for Virology 28th Annual Meeting (Jul 2010).
L.D. Faulkner, N. Chaplot, S.M. Daskalova, M. Goryll, B.G. Hogue. Mutant Coronaviruses with Envelope Protein Transmembrane Changes Known to Significantly Affect Virus Growth Also Exhibit Changes in Ion Channel Activity. American Society for Virology 28th Annual Meeting (Jul 2010).
Hogue, B.G. Virus Structure and Assembly. American Society for Virology 28th Annual Meeting (Jul 2010).
Brenda G. Hogue. Envelope (E) Protein Functions during Coronavirus Assembly. The Ninth International Symposium on Positive-Strand RNA Viruses (May 2010).
Arndt, A.L., Larson, B.J. and Hogue, B.G. Role of the Coronavirus Membrane Protein Cytoplasmic Tail in Virus Assembly. The Ninth International Symposium on Positive-Strand RNA Viruses (May 2010).
Latrice D. Faulkner, Nipun Chaplot, Sashka Daskalova, Ph.D., Michael Goryll, Ph.D., Brenda G. Hogue. Biological Significance of Coronavirus Envelope (E) Protein Ion Channel Activity. Annual Biomedical Research Conference for Minority Students (Nov 2009).
Venkatagopalan, P. and Hogue, B.G. Coronavirus Envelope conserved Proline Residues Are important for Virus Production. American Society for Virology 28ty Annual Meeting (Jul 2009).
Arndt, A.L., Larson, B.J., Altamirano, C.J. and Hogue, B.G. The Role of the Membrane Protein CarboxyTail Conserved Domain in Coronavirus Assembly. American Society for Virology 27ty Annual Meeting (Jul 2009).
Hogue, B.G. Coronaviruses and Arteriviruses I. American Society for Virology 28th Annual Meeting (Jul 2009).
Sotomayor-Castro, Y. , Shelhamer, R., Yi, Z. and Hogue, B.G. Functional Characterization of Mouse Hepatitis Coronavirus Nucleocapsid Protein Phosphorylation. American Society for Virology 28ty Annual Meeting (Jul 2009).
Dolezal, K.A. and Hogue, B.G. A Proteomics Approach to Identifying Potential Host Protein Ineractions with the Coronavirus Envelope Protein. American Society for Virology 28th Annual Meeting (Jul 2009).
Larson, B.J., Dinh, J. Arndt, A.L., Yan, K. Huang, Z. and Hogue, B.G. Construction of Severe Acute Respiratory Syndrome Coronavirus Spike Receptor Binding Domain Fused to Hepatitis B Surface (HBsAg) and Core (HBcAg) Antigens for Vaccine Development. American Society for Virology 28th Annual Meeting (Jul 2009).
A.L. Arndt, B.J. Larson, C.J. Altamirano, and B.G. Hogue. Function of the Coronavirus Membrane Protein Carboxy Tail Conserved Domain. American Society for Microbiology (May 2009).
Venkatagopalan, P. and Hogue, B.G. Significance of Conserved Proline Residues in the Coronavirus Envelope Protein. American Society for Virology 27ty Annual Meeting (Jul 2008).
Sotomayor-Castro, Y. and Hogue, B.G. Functional Characterization of Mouse Hepatitis Coronavirus Nucleocapsid Protein Phosphorylation. American Society for Virology 27ty Annual Meeting (Jul 2008).
Arndt, A.L. and Hogue, B.G. Function of the Coronavirus Membrane Protein Carboxy Tail Conserved Domain. American Society for Virology 27ty Annual Meeting (Jul 2008).
Hogue, B.G. Coronavirus Assembly at Intracellular Membranes. American Society for Virology 27ty Annual Meeting (Jul 2008).
Hogue, B.G. Coronavirus Assembly at Intracellular Membranes. World Congress on In Vitro Biology (Jun 2008).
Hogue, B.G. Coronavirus Envelope Protein Promotes Assembly and Release of Virus. XIth International Nidovirus Symposium, St. Cathrine's College, Oxford University (Jun 2008).
Sotomayor-Castro, Y. and Hogue, B.G. Functional Significance of Identified Phosphorylation Sites on Mouse Hepatitis Coronavirus A59 Nucleocapsid Protein. National Science Foundation Division of Human Resource Development 2008 Joint Annual Meeting (Jun 2008).
Arndt, A.L. and Hogue, B.G. Importance of Conserved Domain in the Coronavirus Membrane Protein Carboxy Tail in Virus Assembly. XIth International Nidovirus Symposium, St. Catherine's College, Oxford University (Jun 2008).
Sotomayor-Castro, Y. and Hogue, B.G. Functional Significance of Identified Phosphorylation Sites on Mouse Hepatitis Coronavirus A59 Nucleocapsid Protein. XIth International Nidovirus Symposium, St. Catherine's College, Oxford University (Jun 2008).
Arndt, A.L. and Hogue, B.G. Role of Coronavirus Membrane Protein Carobxy Tail in Virus Assembly. American Society for Microbiology Meeting, Boston (May 2008).
Hogue, Brenda, Lauer, Jarrod. Coronavirus Polyadenylation and Critical Aspects of Poly(A) Tail Positioning. American Society for Virology 26th Annual Meeting (Jul 2007).
Jones, Ariel, Hogue, Brenda. Role of a Highly Conserved Domain in the Coronavirus membrane Protein Carboxy Tail. American Society for Virology 26th Annual Meeting (Jul 2007).
Lopez, Lisa, Hogue, Brenda. Localization of the Coronavirus Envelope Protein. " American Society for Microbiology Kadner Institute (Jul 2007).
Lopez, Lisa, Hogue, Brenda. Subcellular Localization of the Small Envelope Protein of. " American Society for Microbiology 107th General Meeting (May 2007).
Hogue, Brenda, Lopez, Lisa. Importance of Coronavirus E Protein Conserved Cysteines. Eighth International Symposium on Positive-Strand RNA Viruses (May 2007).
Hogue, Brenda, Ye, Ye. Function and Mechanistic Roles of the Coronavirus E Protein. Eighth International Symposium on Positive-strand RNA Viruses (May 2007).
Hogue, Brenda, Lopez, Lisa. MHV and SARS Coronavirus Envelope Protein Localization. National Graduate Student Symposium (Mar 2007).
Hogue, Brenda. The Multiple Functions of the Coronavirus Nucleocapsid. Department of Microbiology & Immunology and WHO Center for Tropical Disease (Feb 2007).
Hogue, Brenda. A Coronavirus Innate Immune Antogonist. Department of Pathobiological Sciences (Sep 2006).
Hogue, Brenda. Workshop: Virus Modulation and Evasion of Innate Immunity. American Society for Virology 25th Annual Meeting (Jul 2006).
White, T, Niederkofler, E, Bednar, V, Sotomayor, Y, Nelson, R, Hogue, Brenda. Role of Coronavirus Nucleocapsid Phosphorylation. 25th American Society for Virology Meeting (Jul 2006).
Ye, Y, Hauns, K, Jacobs, B, Hogue, Brenda. Coronavirus Alpha/Beta Interferon Antagonists. 25th American Society for Virology Meeting (Jul 2006).
Lopez, L, Hogue, Brenda. Importance of Conserved Cysteine Residues in the Small Evenlope Protein of Coronaviruses. American Society for Microbiology 106th General Meeting (May 2006).
Ye, Y, Hauns, K, Jacobs, B, Hogue, Brenda. Coronavirus Alpha/Beta Interferon Antagonists. Keystone Symposium, Viral Immunity (Mar 2006).
Ye, Y, Hauns, K, Jacobs, B, Hogue, Brenda. Coronavirus Alpha/Beta Interferon Antagonists. Viral Immunity (Mar 2006).
Ye, Ye, Hauns, Kevin, Jacobs, Betram, Hogue, Brenda. Impact of mouse hepatitis coronavirus on eIF2? phosphorylation. XIII international Congress of Virology (Jul 2005).
Ye, Ye, Hauns, K, Jacobs, B, Hogue, Brenda. Mouse Hepatitis Coronavirus Inhibition of eIF2 Alpha Phosphorylation: Implication for Impact on the Interferon Pathway. Xth International Nidovirus Symposium (Jun 2005).
Hogue, Brenda, Ye, Y. Role of the Mouse Hepatitis Coronavirus A59 Envelope Protein Transmembrane Domain in Envelope Formation and Virus Assembly. Xth International Nidovirus Symposium (Jun 2005).
Jones, Ariel, White, T, Arndt, W, Hogue, Brenda. Requirements for Severe Acute Respiratory Syndrome Coronavirus Virus Like Particle Assembly. Xth International Nidovirus Symposium (Jun 2005).
Lopez, Lisa, Arndt, B, White, T, Ye, Y, Hogue, Brenda. Subcellular Localization of the Small Envelope Protein of MHV and SARS Coronaviruses. Xth International Nidovirus Symposium (Jun 2005).
Verma, Sandhya, Bednar, Valerie, Blount, Andrew, Hogue, Brenda. Identification of functionally important negatively charged amino acids in domain II of mouse hepatitis coronavirus A59 nucleocapsid protein. Xth International Nidovirus Symposium (Jun 2005).
White, Tiana, Hogue, Brenda. Mouse Hepatitis Coronavirus Nucleocapsid Phosphorylation. Xth International Nidovirus Symposium (Jun 2005).
Lopez, Lisa, Verma, Sandhya, Bednar, Valerie, Blount, Andrew, Hogue, Brenda. Coronavirus Membrane-Nucleocapsid Interactions in Virus Assembly. American Society for Virology Meeting (Jul 2004).
Verma, Sandhya, Lopez, Lisa, Bednar, Valerie, Blount, Andrew, Hogue, Brenda. Importance of charged amino acids in coronavirus membrane-nucleocapsid interactions during virus assembly. 7th International Symposium on Positive Strand RNA Viruses (May 2004).
Lopez, Lisa, Hogue, Brenda. Role of the Coronavirus Membrane Protein COOH Tail in Virus Assembly. Fourth Annual Minority Graduate Education @Mountain States Alliance Student Research Conference (Mar 2004).
Lopez, L, White, T, Hogue, Brenda. Subcellular Localization of the Small Envelope Protein of MHV & SARS Coronaviruses. 25th American Society for Virology Meeting
Ye, Y, Hogue, Brenda. Importance of the Mouse Hepatitis Coronavirus A59 Envelope Protein Transmembrane Domains in Envelope Formation and Virus Assembly. Xth International Nidovirus Symposium
Hogue, Brenda. Insights Into Coronavirus Assembly - Implications for Vaccine Development. Dept. of Microbiology & Immunology Seminar Series
Hogue, Brenda. Role of the Coronavirus Membrane Protein Carboxy Tail in Virus Assembly. American Society for Virology Meeting
Hogue, Brenda. Role of the Coronavirus Membrane Protein Carboxy Tail in Virus Assembly. IXth International Symposium on Nidoviruses
Hogue, Brenda. The SARS Disease. The Salons
Verma, S, Lopez, L, Hogue, Brenda. Role of the Coronavirus Membrane Protein Carboxy Tail in Virus Assembly. IXth International Symposium on Nidoviruses, Egmond aan Zee
Verma, S, Lopez, L, Hogue, Brenda. Role of the Coronavirus Membrane Protein in Virus Assembly. American Society for Virology Meeting
Lopez, L, Verma, A, Bednar, V, Blount, A, Hogue, Brenda. Coronavirus membrane-nucleocapsid interactions in virus assembly. 23rd American Society for Virology Meeting
Hogue, Brenda. Coronavirus Replication and Assembly.
Hogue, Brenda. Coronavirus Replication and Assembly. Department of Pathobiology
Spagnolo, J, Hogue, Brenda. Requirement of the Poly(A) Tail for Coronavirus RNA Synthesis. 6th International Symposium on Positive Strand RNA Viruses
Hogue, Brenda. Coronavirus Molecular Biology. Molecular Mechanisms of Coronavirus Replication
Hogue, Brenda. Host Protein Interactions With the 3' UTR and Requirement of the Poly(A) Tail. Department of Pathology
Spagnolo, J, Hogue, Brenda. Host Protein Interactions with the 3' UTR and Requirement of the Poly(A) Tail for Coronavirus DI Replication. VIIIth International Symposium on Nidoviruses
Spagnolo, J, Hogue, Brenda. Tail Extension of Coronavirus DI RNAs With Shortened Poly(A). American Society for Virology
Hogue, Brenda. Coronavirus Replication & Assembly. Department of Veterinary Science & Microbiology

Honors/Awards

2014 ASU Devils Advocates Apple Polisher Faculty Recognition Recognition of faculty for their commitment and dedication to student development
2013 ASU Commission on the Status of Women Outstanding Achievement and Contribution Award
2013 ASU Committee for Campus Inclusion Excellence in Diversity Award Nominee

Editorships

Journal of Virology

Virology

Professional Associations

American Society for Virology American Society for Microbiology

Graduate Faculties / Mentoring History

Microbiology Graduate Program Molecular Cellular Biology Graduate Program