David Capco

Professor
Faculty
TEMPE Campus
Mailcode
4501

Biography

David Capco is a cell biologist who studies how different types of cells in the human body relate to disease, illness, and birth defects. Whether studying cells that act as a protective barrier, those that cross barriers, or the signals communicated between those cells, Capco and his team research networks of cells and how cells use communication signals to regulate the healthy body.

Professor Capco’s main focus is on how disease alters cell communication signals and how the body tries to bring the communication system back into balance. Currently, the team focuses on the challenges presented by nanoparticles, which can disrupt protective cellular barriers and negatively impact health. By altering communication signals and nanoparticle exposure, they hope to learn ways to disrupt cancer cell growth.

Education

Ph.D. University of Texas-Austin 1980

Publications

  • Koeneman, B.A., Y. Zhang, P. Westerhoff, Y. Chen, J.C. Crittenden, D.G. Capco (2009). Toxicity and cellular responses of intestinal cells exposed to titanium dioxide. Cell Biol. Toxicol., DOI 10.1007/s10565-009-9132-z.
  • Faust, J. J.M., Kalive, A. Abraham and D.G. Capco (2011). PKC Regulation of Gametogenesis and Early Development. InTech Open Access Meiosis (ISBN 979-953-307-212-7).
  • Kalive, M., W. Zhang, Y. Chen, D.G. Capco (2012) Human intestinal epithelial cells exhibit acellular response indicating a potential toxicity upon exposure to hematite nanoparticles.Cell Bio Toxicology DOI 10.1007/s10565-012-9229-7.
  • Kalive, M., D.P. Baluch, and D.G. Capco (2012) Involvement of PKCzeta and GSK3beta n the stability of the metaphase spindle. InVitro Cell Dev. Biol. 48:97-111.
  • Faust, JJ. & Capco, DG (2013). Multifunctional scaffolds in mammalian eggs: Sites forlocalization, signal transduction and meiotic spindle polarity. Frontiers in Bioscience (Schol.Ed) Jan 1;5:496-506.

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  • Faust, JJ. & Capco, DG. Laser scanning confocal micrograph of a HeLa cell transfected with LifeAct. Ibidi LLC, 2014-2015 product catalogue cover image (2014).
  • Faust, JJ., Doudrick, K., Yang, Y., Westerhoff, P., Capco, DG. Food grade titanium dioxide disrupts intestinal brush border microvilli in vitro independent of sedimentation. Cell Biology and Toxicology (2014).
  • Faust, JJ., Masserano, BM., Mielke, AH., Abraham, A., Capco, DG. Engineered Nanoparticles Induced Brush Border Disruption in a Human Model of the Intestinal Epithelium. Advances in Experimental Medicine and Biology (2014).
  • Faust, JJ., Zhang, W., Chen, Y., Capco, DG. Alpha-Fe2O3 elicits diameter-dependent effects during exposure to an in vitro model of the human placenta. Cell Biology and Toxicology (2014).
  • Reid, R., Faust, JJ., Yang, Yu., Doudrick, K., Capco, DG., Hristovski, K, Westerhoff, P. Characterization of nanomaterials in dietary supplement drinks and assessment of biological interactions across their life cycle. ACS Sustainable Chemistry and Engineering (2014).
  • Edited Book: David G. Capco, ASU and Yongsheng Chen Georgia Institute of Technology. NANOMATERIAL: IMPACTS ON CELL BIOLOGY AND MEDICINE (2014). (2014).
  • Faust, JJ. & Capco, DG. Cells keep their shape with actin filaments and microtubules. (2014).
  • Faust, J.J. & Capco, DG. Laser scanning confocal micrograph of a motile HeLa cell transfected with LifeAct. Ibidi LLC imaging competition, 2013 cover image (2013).
  • James J. Faust and David G. Capco. Multifunctional Scaffolds in Eggs: Sites for Localization, signal transduction and meiotic spindle polarity. Frontiers in Biosciences (2013).
  • Kalive, M., and D.G. Capco. Involvement of MEK, ERK, PKC? and GSK3ß in maintaining the mitotic spindle. International. J. Biology (2013).
  • Faust, JJ. & Capco, DG. Multifunctional scaffolds in mammalian eggs: Sites for localization, signal transduction and meiotic spindle polarity. Frontiers in Bioscience (Schol. Ed) Jan 1;5:496-506 (2013).
  • Faust JJ., Zhang, W., Koeneman, BA., Chen, Y., Capco DG. Commenting on the effects of surface treated- and non-surface treated TiO2 in the Caco-2 cell model. Particle and Fibre Toxicology (2012).
  • Kalive, M., D.P. Baluch, and D.G. Capco. Involvement of PKCzeta and GSK3beta n the stability of the metaphase spindle. In Vitro Cell Dev. Biol (2012).
  • Kalive, M., W. Zhang, Y. Chen, D.G. Capco. Human intestinal epithelial cells exhibit a cellular response indicating a potential toxicity upon exposure to hematite nanoparticles. Cell Biology and Toxicology (2012).
  • Faust, JJ. & Capco, DG. Stereo pair of an embedment-free, detergent-extracted hamster egg at meiotic metaphase II. (2012).
  • Madhavi Kalive, D.Page Baluch, and David. G. Capco. Involvement of PKC? and GSK3ß in the stability of the metaphase spindle. In Vitro Cellular & Developmental Biology (2011).
  • Kalive, M., Faust, J., Koeneman, B.A., Capco, D.G. Involvement of the PKC family in regulation of early development. Molecular Reproduction and Development (2010).
  • Koeneman, B.A. and Capco, D.G. VISIONS: the art of science (Effects of titanium dioxide on human intestinal cells). Molecular Reproduction and Development (2010).
  • Zhang W., Kalive M., Capco DG., Chen Y. Adsorption of hematite nanoparticles onto Caco-2 cells and the cellular impairments: effect of particle size. Nanotechnology (2010).
  • Koeneman, B.A., Y. Zhang, K. Hristovsky, P. Westerhoff, Y. Chen, J.C. Crittenden, D.G. Capco. Experimental approach for an in vitro toxicity assay with non-aggregated quantum dots. Toxicology in vitro (2009).
  • Koeneman, B.A., Y. Zhang, P. Westerhoff, Y. Chen, J.C. Crittenden, D.G. Capco. Toxicity and Cellular Responses of Intestinal Cells Exposed to Titanium Dioxide Nanoparticles. Cell biology and toxicology (2009).
  • Baluch, D. Page and David Capco. GSK3beta mediates acentromeric spindle stabilization by activated PKCdelta. Developmental Biology (2008).
  • A Huang, G Nielson, A Razdan, G Farin, D Baluch, David Capco. Thin structure segmentation adn visualization in three dimensional biomedical images: A shape-based approach. Visualization and Computer Graphics (2006).
  • Koeneman, B, Zhang, Y, Hristovski, K, Westerhoff, P, Chen, Y, Crittenden, J, Capco, David. Effects from the exposure of nanoparticles on human intestinal cells. (2006).
  • Koeneman, B, Panitch, A, He, J, Capco, David. Evaluating the Behavior of NeuralCells Near an Electrode in Rat Brain Slice Cultures. (2005).
  • Koeneman, B, Capco, David George. Cell Signaling. Encyclopedia of Cellular Biology and Molecular (2004).
  • A Panitch, A Singh, B Koeneman, G Raupp, J He, K Lee, David Capco. An ex vivo method for evaluating the biocompatibility of neuronal electrodes in rat brain slice cultures. Journal of Neuroscience Methods (2004).
  • D Baluch, B Koeneman, K Hatch, R McGaughey, David Capco. PKC isotypes in post-activated and fertilized mouse eggs: Association with the meiotic spindle. Developmental Biology (2004).
  • . . A Laboratory Guide of the Mammalian Embryo (2004).
  • J Hu, A Razdan, G Nielson, G Farin, D Baluch, David Capco. Volume segmentation using Weibull E-SD fields. IEEE Transactions on Visualization and Computer Graphics (2003).
  • D Baluch, David Capco. Cellular scaffolds in mammalian eggs. Front. Bioscience (2002).
  • A Razdan, K Patel, G Farnin, David Capco. Volume visualization of multicolor laser confocal microscope data. Computers and Graphics (2001).
  • K Hatch, David Capco. Co-localization of CaM KII and MAP Kinase on architectural elements of the mouse egg: Potentiation of MAP Kinase activity by CaM KII. Molecular Reproduction and Development (2001).
  • Capco, David George. Molecular and Biochemical regulation of pre-implantation development. (2001).
  • C Pauken, David Capco. The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development. Developmental Biology (2000).
  • Koeneman, B.A. and Capco, D.G. VISIONS: the art of science (Mouse embryonic stem cells co-cultured with living rat brain slices). Molecular Reproduction and Development (0).
  • Faust, J.J. & Capco, DG (2013). Laser scanning confocal micrograph of a motile HeLa cell transfected with LifeAct. Ibidi LLC imaging competition, 2013 cover image. Laser scanning confocal micrograph of a motile HeLa cell transfected with LifeAct. (0).
  • Faust, JJ. & Capco, DG. Stereo pair of an embedment-free, detergent-extracted hamster egg at the 8-cell stage. (0).

Research Activity

Courses

Fall 2019
Course Number Course Title
BIO 181 General Biology I
BIO 353 Cell Biology
BIO 394 Special Topics
BIO 492 Honors Directed Study
BIO 493 Honors Thesis
Summer 2019
Course Number Course Title
BIO 181 General Biology I
BIO 353 Cell Biology
Spring 2019
Course Number Course Title
BIO 181 General Biology I
BIO 353 Cell Biology
BIO 394 Special Topics
BIO 492 Honors Directed Study
BIO 495 Undergraduate Research
BIO 499 Individualized Instruction
Fall 2018
Course Number Course Title
BIO 181 General Biology I
BIO 353 Cell Biology
BIO 394 Special Topics
BIO 492 Honors Directed Study
BIO 493 Honors Thesis
Summer 2018
Course Number Course Title
BIO 181 General Biology I
BIO 353 Cell Biology
Spring 2018
Course Number Course Title
BIO 492 Honors Directed Study
BIO 495 Undergraduate Research
BIO 499 Individualized Instruction
Fall 2017
Course Number Course Title
BIO 181 General Biology I
BIO 310 Special Problems & Techniques
BIO 493 Honors Thesis
BIO 499 Individualized Instruction
Summer 2017
Course Number Course Title
BIO 181 General Biology I
BIO 353 Cell Biology
Spring 2017
Course Number Course Title
BIO 181 General Biology I
BIO 492 Honors Directed Study
BIO 495 Undergraduate Research
BIO 499 Individualized Instruction
Fall 2016
Course Number Course Title
BIO 181 General Biology I
BIO 310 Special Problems & Techniques
BIO 353 Cell Biology
BIO 493 Honors Thesis
BIO 499 Individualized Instruction
Summer 2016
Course Number Course Title
BIO 181 General Biology I
BIO 353 Cell Biology
MCB 598 Special Topics
Spring 2016
Course Number Course Title
BIO 492 Honors Directed Study
BIO 494 Special Topics
MBB 494 Special Topics
BIO 495 Undergraduate Research
BIO 499 Individualized Instruction
BIO 564 Cellular Physiology & Signalng
Fall 2015
Course Number Course Title
BIO 189 Life Sciences Career Paths
BIO 310 Special Problems & Techniques
BIO 353 Cell Biology
BIO 493 Honors Thesis
BIO 499 Individualized Instruction
Summer 2015
Course Number Course Title
BIO 181 General Biology I
BIO 353 Cell Biology
MCB 598 Special Topics
Spring 2015
Course Number Course Title
BIO 492 Honors Directed Study
BIO 494 Special Topics
MBB 494 Special Topics
BIO 495 Undergraduate Research
BIO 564 Cellular Physiology & Signalng

Presentations

  • Faust, JJ., Doudrick, K., Yang, Y., Westerhoff, P., Capco, DG. Food grade titanium dioxide disrupts intestinal brush border microvilli in vitro independent of sedimentation. Arizona Imaging and Microanalysis Society Annual Meeting 2014 (Apr 2014).
  • Kalive, M. Faust, J.J., Koeneman, B.A. and Capco, D.G. The effect of nanohematite on human intentinal (Caco-2) cells. Molecular and Cellular Biology Retreat (Sep 2009).
  • Faust, JJ., Koeneman, BA., Baluch, DP., Capco, DG. Evaluation of epithelial lines for toxicity testing. UBEP Research Symposium (May 2009).
  • Koeneman B.A., G. Golden, D.G. Capco. Intracellular Calcium Signaling in Mouse Eggs. Molecular and Cellular Biology Colloquium (Oct 2008).
  • Ciraola, D., J. Faust, A. Baird, C. Newburg, B.A. Koeneman, D.G. Capco. Acentromeric and centromeric spindles and their assembly. 15th Annual UBEP Research Symposium (Mar 2008).
  • Koeneman B.A., Y. Zhang, K. Hristovski , P. Westerhoff, Y. Chen, J. Crittenden, D.G. Capco. Cytotoxicity Effects of Nananoparticles in Drinking Water. 9th Annual Graduates in Earth., Life, and Social Sciences Annual Symposium, (Feb 2008).
  • Capco, David. The Relationship Between CaM Kinase II and MAP Kinase in the Development of Mammalian Eggs. CLAS Research Symposium, Arizona State University (Mar 2007).
  • Baluch, D, Koeneman, B, McGaughey, R, Capco, David. Unique association of PKC zeta at the meiotic spindle. Society for Reproduction (Jun 2004).
  • Capco, David. Awarded Best Life Sciences Poster: Impact of Nanoparticles on Human Intestinal Cells. Arizona Imaging and Microanalysis Society Annual Meeting
  • Capco, David. Cytotoxicity of Nanoparticles on Human Intestinal Cells. The American Society for Cell Biology 47th Annual Meeting
  • Capco, David. Effects of Nanoparticle Exposure to Human Intestinal Cells. Molecular and Cell Biology Colloquium
  • Capco, David. Fate, Transport, and Toxicity of Nanomaterials in Drinking Water. Nanoscience and Technology Annual Meeting
  • Capco, David. Nanoparticles in Water Environment: Characterization, Removal, Environmental Applications. Bioaccumulation and cytotoxicity, International Workshop on Environmental Engineering
  • Capco, David. Titanium Dioxide Nanoparticles: Potential Toxic Effects on Human Intestinal Cells, Honors Thesis Symposium. Honors Thesis Symposium, Arizona State University
  • Capco, David. Titanium Dioxide: Potential Toxic Effects on Human Intestinal Cells. 14th Annual UBEP Research Symposium, Arizona State University
  • Baluch, D, Koeneman, B, McGaughey, R, Capco, David. A possible role of PKC zeta in maintaining spindle integrity. American Society for Cell Biology

Service

  • Ad hoc reviewer for NSF, Reviewer (2005 - Present)
  • Ad hoc reviewer for NSF, Reviewer (2005 - Present)
  • Ad hoc reviewer for NSF, Reviewer (2005 - Present)
  • Ad hoc reviewer for NSF, Reviewer (2005 - Present)
  • Ad hoc reviewer for NSF, Welcome Foundation, Reviewer (2005 - Present)
  • Ad hoc reviewer for NSF, Welcome Foundation, Reviewer (2005 - Present)
  • Peer reviewer for manuscripts from Biology of Reproduction journal, Developmental Biology Journal, Reviewer (2005 - Present)
  • Peer reviewer for manuscripts from Biology of Reproduction journal, Developmental Biology Journal, Reviewer (2005 - Present)
  • Peer reviewer for manuscripts from Biology of Reproduction journal, Developmental Biology Journal, Reviewer (2005 - Present)
  • Peer reviewer for manuscripts from Biology of Reproduction journal, Developmental Biology Journal, Reviewer (2005 - Present)
  • Editoral Board, Frontiers in Bioscience, Member (2001 - Present)
  • Molecular Reproduction and Development, Associate Editor (1999 - Present)
  • Molecular Reproduction and Development, Associate Editor (1999 - Present)
  • Molecular Reproduction and Development, Associate Editor (1999 - Present)
  • SOLS Undergraduate Program Committee, Member (2014 - 2014)
  • Legacy of Dao, Secretary and Board Member (2014 - 2014)
  • SOLS Freshman Retention, co-organizer (2012 - 2014)
  • School of Life Sciences, Faculty area advisor for Genetics, Cell and Developmental Biology/SOLS (2012 - 2014)
  • Ad hoc reviewer for NSF, Reviewer (2005 - 2014)
  • Peer reviewer Biol of Reprod., Develop. Biol., Nanotox ltrs, Cell Biol. &Toxicol, Reviewer (2005 - 2014)
  • Molecular Reproduction and Development, Associate Editor (1999 - 2014)
  • Ad hoc reviewer for NSF, Reviewer (2005 - 2013)
  • Peer reviewer Biol of Reprod., Develop. Biol., Nanotox ltrs, Cell Biol. &Toxicol, Reviewer (2005 - 2013)
  • Molecular Reproduction and Development, Associate Editor (1999 - 2013)
  • Barrett Honors College, Faculty area advisor for Genetics, Cell and Developmental Biology/SOLS (2012 - 2013)
  • Barrett Honors College, Faculty area advisor for Genetics, Cell and Developmental Biology/SOLS (2012 - 2012)
  • Legacy of Dao, Secretary and Board Member (2012 - 2012)
  • SOLS Freshman Retention, co-organizer (2012 - 2012)
  • School of Life Sciences, Faculty area advisor for Genetics, Cell and Developmental Biology/SOLS (2012 - 2012)
  • Legacy of Dao, Secretary and Board Member (2010 - 2012)
  • Ad hoc reviewer for NSF, Reviewer (2005 - 2012)
  • Peer reviewer for manuscripts from Biology of Reproduction journal, Developmental Biology Journal, Reviewer (2005 - 2012)
  • Molecular Reproduction and Development, Associate Editor (1999 - 2012)
  • SOLS Freshman Retention, co-organizer (2010 - 2011)
  • SOLS Undergraduate Curriculum Reform Committee, Member (2010 - 2011)
  • SOLS Undergraduate Program Committe, Member (2005 - 2011)
  • Legacy of Dao, Secretary and Board Member (2009 - 2010)
  • CLAS Freshman Retention, Lead Faculty, Medicine, Culture, and Healing CLAS Learning Community (2009 - 2009)
  • CLAS Freshman Retention, Lead Faculty, Medicine, Culture, and Healing CLAS Learning Community (2009 - 2009)
  • CLAS Freshman Retention, Lead Faculty, Medicine, Culture, and Healing CLAS Learning Community (2008 - 2008)
  • Legacy of Dao, Founding Board member (2007 - 2008)
  • Lead Faculty, Medicine, Culture, and Healing CLAS Learning Community (2007 - 2007)
  • SOLS Undergraduate Program Committee member, member (2007 - 2007)
  • ASU EAST, Presenter in their Alternative Medicine Series (2006 - 2007)
  • Maricopa Community College District Strategic Taskforce on Biotechnology, member (2003 - 2007)
  • Frontiers in Bioscience, Editoral Board (2007)
  • Journals: Developmental Biology, Biology of Reproduction, Peer Reviewer (2007)
  • Legacy of Dao, Founding Board member (2007)
  • Molecular Reproduction and Development, Associate Editor (2007)
  • Southwest Institute of Healing Arts, Lecturer (2007 - 2007)
  • SoLS Medicine, Culture, and Healing Learning Community (MCH LC), Developer, Director and Faculty Leader of the new MCH LC (2006 - 2006)
  • SoLS Undergraduate Program Committee, Member (2006 - 2006)
  • CLAS Learning Community entitled Human Disease and Society, Lead faculty Spring Semester, Co-Director (2004 - 2006)
  • Maricopa Community College District Strategic Taskforce on Biotechnology, Member (2003 - 2006)
  • Frontiers in Bioscience, Editoral Board (2004)
  • Glendale Community College, presentation on Biotechnology and Cell Culture, 2004, Presenter (2004)
  • Maricopa Community College District Strategic Taskforce on Biotechnology, member (2004)
  • Personnel Committee, Cellular and Mol Bioscience Faculty/SoLS, Member (2004)
  • Steering Committee Battelle Study on Maricopa Bioindustry Workforce Commission, member (2004)
  • peer reviewer for manuscripts from Biology of Reproduction journal, Developmental Biology Journal, Reviewer (2004)
  • Department of Biology Advisory Committee, Member (2003 - 2003)
  • Development Group: SOLS Learning Community entitled Human Disease and Society, Member (2003 - 2003)
  • Development Group: SOLS freshman course "Career Paths in the Life Sciences, Member (2003 - 2003)
  • SOLS Molecular Genetics Search Committee, Member (2003 - 2003)
  • SOLS ad hoc committee on the Website, Member (2003 - 2003)
  • Arizona Bioindustry Cluster, Chair, Nominating Committee (2002 - 2003)
  • Nominating Committee, Arizona BioIndustry Cluster, Chair (2002 - 2003)
  • Arizona Bioindustry Association, Chair, Nominating Committee (2001 - 2003)
  • Campus Environment Team, ASU President's Committee, Member (2001 - 2003)
  • Board of Directors, Arizona Bioindustry Cluster, Inc, Member (2000 - 2003)
  • Arizona Bioindustry Cluster, Board of Directors, member (1999 - 2003)
  • Arizona Bioindustry Association, Elected Member, Board of Directors (1998 - 2003)
  • ASU Campus Environment Team (President's Committee), Member (2003)
  • Department of Biology Advisory Committee, Member (2003)
  • SoLS Molecualr Genetics Search Committee, Member (2003)
  • Sols Development group for Career Paths in the Life Sciences, Co-instructor/developer (2003)
  • MCB Program ad hoc committee on the Website, Member (2000 - 2002)
  • Molecular and Biochemical Regulation of Mammalian Pre-Implantion Development for Frontiers in Bioscience, Managing Editor (2000 - 2002)
  • MCB Programad hoc committee on revision of Comprehensive Exams, Member (2000 - 2001)
  • MCB Program Admission Committee, Member (2000 - 2000)