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Tatiana Ugarova

Tatiana Ugarova
ISTB1, Room 481 D
TEMPE
Professor
Faculty
TEMPE Campus
Mailcode
4501

Publications

  • Owaynat, H., Yermolenko, I.S., Turaga, R., Lishko, V.K., Sheller, M. and Ugarova, T.P. Limiting mechanisms of thrombus propagation: Deposition of fibrinogen on the surface of blood clots prevents platelet adhesion. Thrombosis Research (2015).
  • Podolnikova, N.P. Podolnikov, A.V., Lishko, VK, T. Haas, T and Ugarova, T.P. Ligand 2. recognition specificity of leukocyte integrin aMß2 (Mac-1, CD11b/CD18) and its functional 3. consequences,. Biochemistry (2015).
  • Podolnikova, N.P., Brothwell, J.A., Ugarova, T.P. The opioid peptide dynorphin A induces leukocyte responses via integrin Mac-1 (aMß2, CD11b/CD18). Molecular Pain (2015).
  • Safiullin, R., Christenson, W., Owaynat, H., Yermolenko, I.S., Kadirov, M.K., Ros, R., Ugarova, T.P. Fibrinogen matrix deposited on the surface of biomaterials acts as a natural anti-adhesive coating. Biomaterials (2015).
  • Tsen, S.D.; Kibler, K., Jacobs, B., Fay, J.C., Podolnikova, N.P., Ugarova, T.P., Achilefu, S., Tsen, K. Selective photonic disinfection of cell culture using a visible ultrashort pulsed laser. Selected Topics in Quantum Electronics (2015).
  • Lishko, V., Moreno, B., Podolnikova, N., Ugarova, T. Identification of the Antimicrobial Peptide LL-37 as a Ligand for Integrin aMß2 (Mac-1, CD11b/CD18) Reveals its Role in Macrophage Phagocytosis. FASEB Journal (2015).
  • Podolnikova, N., Lishko, V., Haas, T. and Ugarova, T. Recognition Specificity of Leukocyte Integrin aMß2 (Mac-1, CD11b/CD18) and its Functional Consequences. FASEB Journal (2015).
  • Christenson, W.B., *Yermolenko, I.S., Plochberger, B., Camacho-Alanis, F., Ros, A., Ugarova, T.P. and Ros, R. Combined single cell AFM manipulation and TIRFM for probing the molecular stability of multilayer fibrinogen matrices. Ultramicroscopy (2014).
  • Gorbatyuk, v., Nguyen, K., Podolnikova, N.P., Deshmukh, L., Lin, X., Ugarova, T.P., Vinogradova, O. Skelemin association with aIIbß3 integrin: A structural model. Biochemistry (2014).
  • V. K. Lishko, I. S. Yermolenko, N. P. Podolnikova and T. P. Ugarova. A NOVEL MECHANISM CONTROLLING THE GROWTH OF HEMOSTATIC THROMBI. Ukrainian Biochemical Journal. Anniversary Issue (2014).
  • Safiullin, R., Yermolenko, I.S., Lishko, V.K., Kadirov, M.K., Ros, R., Ugarova, T.P. Fibrinogen matrix deposited on the surface of biomaterials acts as a natural anti-adhesive coating. Proceedings of the XXIII International Fibrinogen Workshop, Marseille, France (2014).
  • Yermolenko, I.S., Turaga, R., Sheller, M., Ugarova, T.P. Self-limiting mechanisms of thrombus propagation: the role of fibrinogen. Proceedings of the XXIII International Fibrinogen Workshop, Marseille, France (2014).
  • Christenson, W.B., Yermolenko, I.S., Plochberger, B., Camacho-Alanis, F., Ros, A., Ugarova, T.P. and Ros, R. Combined single cell AFM manipulation and TIRFM for probing the molecular stability of multilayer fibrinogen matrices. Ultramicroscopy (2013).
  • Podolnikova, N.P., Yakovlev, S., Yakubenko, V.P., Wang, X., Gorkun, O.V., Ugarova, T.P. The interaction of integrin aiibß3 with fibrin occurs through multiple binding sites in the aiib ß-propeller domain. Journal of Biological Chemostry (2013).
  • Christenson, W.B., Yermolenko, I.S., Alanis, F.C., Ros, A., Ugarova, T.P., Ros, R. Molecular stability of the nonadhesive fibrinogen multilayer. Biophysical Journal 57th Annual Meeting of Biophysical Society, February, 2013 (2013).
  • Kyubeom Oh, Podolnikova, N.P., Mandarino, L., Ugarova, T. Weight gain and changes in the polarization of fat macrophages towards the M1-Like proinflammatory phenotype in integrin Mac-1 (CD11b/CD18) deficient mice. Proceedings of the 73rd scientific sessions of the American Diabetes Association (2013).
  • Owaynat, H., Lishko, V.K., Faust, J.J., Ugarova, T.P. The dual role of platelets in thrombus formation. Blood (2013).
  • Podolnikova, N.P., Kyubeom Oh, Yermolenko, I.S., Ugarova, T.P. An altered An altered macrophage migration in adipose tissue of integrin Mac-1 (CD11b/CD18) deficient mice. Blood (2013).
  • Lishko, V.K., Yermolenko, I.S., Owaynat H., Ugarova T. Fibrinogen counteracts the anti-adhesive effect of fibrin-plasminogen by preventing its activation by adherent U937 cells. Journal of Thrombosis and Hemostasis (2012).
  • Yermolenko, I.S., Gorkun, O.V., Fuhrmann, A., Podolnikova, N.P. Lishko, V.K., Lord, S.T., Ros, R., Ugarova, T.P. The assembly of nonadhesive fibrinogen matrices depends on the aC regions of the fibrinogen molecule. Journal of Biological Chemistry (2012).
  • Wu, Y., Kushchaeva, Y., Ugarova, T.P. The role of integrins aMb2 (CD11b/CD18) and adb2 (CD11d/CD18) in macrophage fusion. Blood (2012).
  • Yermolenko, I.S., Bryant, Doss, Robert Ros, Tatiana P. Ugarova. The mechanism of the formation of nonadhesive fibrinogen matrices examined by atomic force microscopy. Biophysical Journal (2012).
  • Yermolenko, I.S., Lishko, V.K., Ugarova, T.P., Magonov, S.N. High-resolution visualization of fibrinogen molecules and fibrin fibrils with atomic force microscopy. Biomacromolecules (2011).
  • Podolnikova, N., Yakubenko, V. Ugarova, T. Molecular basis for fibrin binding by platelet integrin aIIbb3. Journal of Thrombosis and Hemostasis (2011).
  • Yermolenko, IS, Gorkun, OV, Fuhrmann, A, Lishko, VK, Lord, ST, Ros, R, Ugarova, TP,. The role of the gammaC domains in the formation of nonadhesive fibrinogen matrices. Blood (2011).
  • Derkach, D.N., Wadekar, S.A., Perkins, K.B., Rousseau, E., Dreiza, C.M., Cheung-Flynn, J., Ramos, H.C., Ugarova, T.P. and Sheller, M.R. RGD-dependent binding of TP508 to integrin ?v?3 mediates cell adhesion and induction of nitric oxide. Thrombosis and Hemostasis (2010).
  • Lishko, V.K., Yermolenko, I.S. and Ugarova, T.P. Plasminogen on the surface of fibrin clot prevents adhesion of leukocytes and platelets. Journal of Thrombosis and Haemostasis (2010).
  • Lishko, V.K., Yermolenko, I.S. and Ugarova, T.P. Plasminogen on the surface of fibrin clot prevents adhesion of leukocytes and platelets. Journal of Thrombosis and Haemostasis, (2010).
  • Podolnikova, N., Yermolenko, I., Fuhrmann, A., Lishko, V., Magonov, S.,Bowen, B., Podolnikov, A., Ros, R. and Ugarova, T.P. Control of integrin ?IIb?3 outside-in signaling and platelet adhesion by sensing the physical properties of fibrin(ogen) substrates. Biochemistry (2010).
  • Yermolenko, I.S., Fuhrmann, A. Magonov, S.N., Lishko, V.K., Oshkadyerov, S.P., Ros R., Ugarova, T.P. Origin of the nonadhesive properties of fibrinogen matrices probed by force spectroscopy. Langmuir (2010).
  • Yermolenko, I., Fuhrmann, A., Ugarova, T.P., Ros, R. Physical Properties of Fibrinogen Substrates Control Integrin Mediated Cell Adhesion. Biophysical Journal (2010).
  • Podolnikova N.P, O’Toole T.E, Haas, T.A., Lam S.C, Fox J.E.B and Ugarova TP. Adhesion-induced unclasping of cytoplasmic tails of integrin aIIbb3. Biochemistry (2009).
  • Valentin Yakubenko, Tatiana Ugarova. The role of integrin aDb2 in monocyte/macrophage migration. Experimental Cell Research (2008).
  • Derkach D, Wadekar S, Rousseau E, Ugarova T, Perkins K, Sheller M. Cell Adhesion to Thrombin Peptide, TP508, is RGD-Dependent and Mediated by Integrin aVb3. American Society of Cell Biology 48th Annual Metting, San Francisco, CA (2008).
  • Podolnikova, N., Bowen, B., Lishko, V., Ugarova, T. Control of integrin-mediated platelet adhesion by rigidity sensing at the surface of fibrin(ogen) sustrates. FASEB J (2008).
  • Podolnikova, N., Bowen, B., Lishko, V., Ugarova, T. Control of integrin-mediated platelet adhesion by rigidity sensing at the surface of fibrin(ogen) substrates. Proceedings of the XXth International Fibrinogen Workshop (2008).
  • V Lishko, T Burke, Tatiana Ugarova. Anti-adhesive effect of fibrinogen: A safeguard for thrombus stability. Blood (2007).
  • V Yakubenko, S Yadav, Tatiana Ugarova. Integrin alphaDbeta2, an adhesion receptor upregulated in macrophage foam cells, exhibits multiligand binding properties. Blood (2006).
  • Lishko, Valeryi, Ugarova, Tatiana. Plasminogen protects fibrin clot from leukocyte invasion. (2006).
  • Podolnikova, N, O'Toole, T, Fox, J, Lam, S, Ugarova, Tatiana. Conformational changes in the cytoplasmic domain of integrin alphaIIbbeta3 induced by adhesion of resting platelets to fibrin(ogen). (2006).
  • N Podolnikova, O Gorkun, R Loreth, S Lord, V Yee, Tatiana Ugarova. A cluster of basic amino acid residues in the ?370-381 sequence of fibrinogen comprises a binding site for platelet integrin ??IIb?3 (GPIIb/IIIa). Biochemistry (2005).
  • S Yakovlev, L Zhang, Tatiana Ugarova. Interaction of fibrin(ogen) with leukocyte receptor ?M?2: Further characterization and identification of a novel binding region within the central domain of the fibrinogen ?-module. Biochemistry (2005).
  • N Podolnikova, G Volkov, Tatiana Ugarova. Structure function analysis of the P3 peptide identical to ?370-383, the binding site for integrin ?IIb?3 within the ?C-domain of fibrinogen. Ukr. Biochem. J (2004).
  • V Lishko, N Podolnikova, V Yakubenko, S Yakovlev, L Medved, S Yadav, Tatiana Ugarova. Multiple binding sites in fibrinogen for integrin ?M?2 (Mac-1). J Biol Chem (2004).
  • V Lishko, V Novokhatny, V Yakubenko, H Skomorovskaja-Prokvolit, Tatiana Ugarova. Characterization of plasminogen as an adhesive ligand for integrins ?M?2(Mac-1) and ?5?1(VLA-5). Blood (2004).
  • J Schober, Lester Lau, Tatiana Ugarova, S Lam. Identification of a novel integrin ?M?2 binding site in CCN1 (CYR61), a matricellular protein expressed in healing wounds and atherosclerotic lesions. J. Biol. Chem (2003).
  • N Podolnikova, V Yakubenko, E Plow, Tatiana Ugarova. Identification of a novel binding site for platelet integrins ?IIb?3(GPIIbIIIa) and ?5?1 in the ?C-domain of fibrinogen. J. Biol. Chem (2003).
  • Tatiana Ugarova, V Lishko, N Podolnikova, N Okumura, S Merkulov, V Yakubenko, V Yee, S Lord, T Haas. Sequence ?383-395 (P2-C) but not ?190-202 (P1) is binding site for the ?MI-domain of integrin ?M?2??in the ?C-domain of fibrinogen. Biochemistry (2003).
  • V Lishko, V Yakubenko, Tatiana Ugarova. The interplay between integrins ?M?2 and ?5?1 during cell migration to fibronectin. Exp. Cell Research (2003).
  • J Schober, N Chen, T Grzeskiewich, E Emeson, Tatiana Ugarova, R Yee, L Lau, S Lam. Identification of integrin ?M?2 as an adhesion receptor on peripheral blood monocytes for Cyr61 and connective tissue growth factor, immediate-early gene products expressed in atherosclerotic lesions. Blood (2002).
  • V Lishko, B Kudryk, V Yee, Tatiana Ugarova. Regulated exposure of the cryptic binding site for leukocyte integrin ?M?2 in the ?C-domain of fibrinogen. Biochemistry (2002).
  • V Yakubenko, V Lishko, S Lam, Tatiana Ugarova. A molecular basis for inetgrin ?M?2 ligand binding promiscuity. J. Biol. Chem (2002).
  • C Forsyth, D Solovjov, Tatiana Ugarova, E Plow. Integrin ?M?2-mediated cell migration to fibrinogen and recognition peptides. J. Exp. Med (2001).
  • Tatiana Ugarova, V Yakubenko. Recognition of fibrinogen by leukocyte integrins: A molecular link between hemostasis and inflammation. Ann. New York Acad. Sci (2001).
  • V Lishko, V Yakubenko, K Hertzberg, G Grieninger, Tatiana Ugarova. The alternatively spliced ?EC domain of fibrinogen-420 is a novel ligand for leukocyte integrins ?M?2 and ?X?2 integrins. Blood (2001).
  • V Yakubenko, D Solovjov, L Zhang, V Yee, E Plow, Tatiana Ugarova. Identification of the binding site for fibrinogen recognition peptide ?383-395 within the ?MI- domain of integrin ?M?2. J. Biol. Chem (2001).
  • W Hu, J Eaton, Tatiana Ugarova, L Tang. Molecular basis of biomaterial-mediated foreign body reactions. Blood (2001).
  • B Johnston, A Chee, T Issekutz, Tatiana Ugarova, A Fox-Robinchaud, M Hichey, P Kubes. ?4-integrin-dependent leukocyte recruitment does not require VCAM-1 in a chronic model of inflammation. J. Immunology (2000).
  • K McClary, Tatiana Ugarova, D Grainger. Modulating fibroblast adhesion, spreading and proliferation using self-assembled monolayer films of alkylthiolates on gold. Journal of Biomedical Materials Research (2000).
  • V Yakubenko, R Lobb, E Plow, Tatiana Ugarova. Differential induction of gelatinase B (MMP-9) and gelatinase A (MMP-2) in T-lymphocytes through ?4?1-mediated adhesion to VCAM-1 and the CS-1 peptide of fibronectin. Exp. Cell. Res (2000).

Research Activity

  • Ugarova,Tatiana P*, Ros,Robert. Molecular basis for nonadhesive properties of fibrinogen matrices. HHS-NIH-NHLBI(4/6/2011 - 8/31/2016).
  • Ugarova,Tatiana P*, Ugarova,Tatiana P*. Recognition of Fibrinogen by Leukocyte Integrins. HHS-NIH-NHLBI(12/1/2010 - 7/31/2019).
  • Ugarova,Tatiana P. Origin of the nonadhesive properties of fibrinogen matrices probed by atomic force spectroscopy. (7/1/2010 - 6/30/2012).
  • Ugarova,Tatiana P. Recognition of Fibrinogen by Leukocyte Integrins. HHS-NIH-NHLBI(10/1/2007 - 11/30/2010).
  • Ugarova,Tatiana P. Recognition of Fibrinogen by Leukocyte Integrins. HHS-NIH-NHLBI(8/15/2006 - 10/1/2007).

Courses

Summer 2020
Course Number Course Title
MBB 495 Undergraduate Research
Spring 2020
Course Number Course Title
BIO 353 Cell Biology
BIO 394 Special Topics
BIO 495 Undergraduate Research
Fall 2019
Course Number Course Title
BIO 495 Undergraduate Research
MBB 495 Undergraduate Research
NEU 555 Adv Molecular & Cellular Sci
MCB 555 Adv Molecular & Cellular Sci
Summer 2019
Course Number Course Title
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
Spring 2019
Course Number Course Title
BIO 353 Cell Biology
BIO 394 Special Topics
BIO 495 Undergraduate Research
Fall 2018
Course Number Course Title
BIO 495 Undergraduate Research
MBB 495 Undergraduate Research
NEU 555 Adv Molecular & Cellular Sci
MCB 555 Adv Molecular & Cellular Sci
Summer 2018
Course Number Course Title
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
Spring 2018
Course Number Course Title
BIO 353 Cell Biology
BIO 394 Special Topics
BIO 495 Undergraduate Research
Fall 2017
Course Number Course Title
BIO 495 Undergraduate Research
MBB 495 Undergraduate Research
NEU 555 Adv Molecular & Cellular Sci
MCB 555 Adv Molecular & Cellular Sci
Summer 2017
Course Number Course Title
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
Spring 2017
Course Number Course Title
BIO 353 Cell Biology
Fall 2016
Course Number Course Title
BIO 495 Undergraduate Research
MBB 495 Undergraduate Research
NEU 555 Adv Molecular & Cellular Sci
MCB 555 Adv Molecular & Cellular Sci
Summer 2016
Course Number Course Title
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
Spring 2016
Course Number Course Title
BIO 353 Cell Biology
Fall 2015
Course Number Course Title
MBB 495 Undergraduate Research
NEU 555 Adv Molecular & Cellular Sci
MCB 555 Adv Molecular & Cellular Sci

Service

  • The International Fibrinogen Research Society, Elected Treasurer (2014 - Present)
  • The International Fibrinogen Research Society, Elected Treasurer (2014 - Present)
  • Faculty Search Committee for a position in Biomarkers at the rank of Assistant Professor, SoLS, Member (2012 - Present)
  • Keck Bioimaging Laboratory Advisory Committee, Member (2012 - Present)
  • Keck Bioimaging Laboratory Advisory Committee, Member (2012 - Present)
  • Maryland Industrial Partnership, Reviewer (2011 - Present)
  • Search Committee for two positions in metabolic biology for SoLS, Member (2010 - Present)
  • Search Committee for two positions in microbiology for SoLS and Biodesign Institute, Member (2010 - Present)
  • Search Committee for two positions for the Department of Chemistry and Biochemistry, Member (2009 - Present)
  • NIH HT Study Section, Reviewer (2008 - Present)
  • Search Committee for two positions in Metabolic Biology, Member (2007 - Present)
  • SoLS Research and Training Initiatives Committee, Member (2007 - Present)
  • SoLS Research and Training Initiatives Committee, Member (2007 - Present)
  • SoLS Research and Training Initiatives Committee, Member (2007 - Present)
  • SoLS Research and Training Initiatives Committee, Member (2007 - Present)
  • American Heart Association Thrombosis Study Section, Reviewer (2006 - Present)
  • Thrombosis and Hamostasis, Reviewer (2006 - Present)
  • Thrombosis and Hemostasis, Reviewer (2006 - Present)
  • The International Fibrinogen Research Society, Member, Board of Gobernors (2003 - Present)
  • The International Fibrinogen Research Society, Member, Board of Counselors (2003 - Present)
  • The International Fibrinogen Research Society, Board of Counselors (2003 - Present)
  • The International Fibrinogen Research Society, Member of the Board of Counselors (2003 - Present)
  • The International Fibrinogen Research Society, Member of the Board of Counselors (2003 - Present)
  • The International Fibrinogen Research Society, Member of the Board of Counselors (2003 - Present)
  • The International Fibrinogen Research Society, Member of the Board of Counselors (2003 - Present)
  • NIH Hemostasis and Thrombosis Study section, Member (2011 - 2016)
  • NIH Hemostasis and Thrpmbosis Study section, Member (2011 - 2016)
  • NIH HT Study section, Member (2011 - 2015)
  • NIH HT Study section, NIH HT Study section (2011 - 2015)
  • Faculty Search Committee for a position in Biomarkers at the rank of Assistant Professor, SoLS, Memeber (2014 - 2015)
  • Faculty Search Committee for a position in Biomarkers at the rank of Assistant Professor, SoLS, Memeber (2012 - 2013)
  • School of Life Sciences Research and Training Initiatives Committee, Member (2007 - 2012)
  • The International Fibrinogen Research Society, Board of Counselors (2003 - 2010)
  • Search Committee for two positions for the Department of Chemistry and Biochemistry, Member (2009 - 2010)
  • Georgian National Science Foundation, Reviewer (2007 - 2007)
  • NIH Study Section, Reviewer (2007 - 2007)
  • American Heart Association, Member of the Thrombosis Study Section (2006 - 2006)
  • 11th Midwest Platelet Conference, Chicago, Invited Speaker (2006 - 2006)
  • XIX international Fibrinogen Workshop, Surrey, UK, Speaker (2006 - 2006)
  • Interactions of fibrinogen with cells and receptor, XVII International Fibrinogen Workshop, Chairman (2004 - 2004)
  • XVIIIth International Fibrinogen Workshop, Chapel Hill, NC, Speaker (2004 - 2004)
  • 16th International Congress of the International Society for Fibrinolysis and Proteolysis, Munich, Speaker (2002 - 2002)
  • 75th session of the American Heart Association, Chicago, Speaker (2002 - 2002)
  • Interactions of fibrinogen with biomaterials, 16th International Congress of the International Society for Fibrinolysis and Proteolysis (ISFP), Chairman (2002 - 2002)
  • XVIIIth Congress of ISTH, Paris, France, Speaker (2001 - 2001)
  • XVIIth Congress of ISTH, Washington, D.C, Invited Speaker (2000 - 2000)
  • XVIth International Fibrinogen Workshop, Leiden, Netherlands, Invited Speaker (2000 - 2000)