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Xuan Wang

Office 499E Biodesign C
1001 S. McAllister
ASU
Tempe
Associate Professor
Faculty
TEMPE Campus
Mailcode
4501

Biography

Xuan Wang is a microbiologist interested in developing new microbial fermentation processes for the production of renewable bio-based chemicals. He received his BS from University of Science and Technology of China and obtained MS from Chinese Academy of Sciences (CAS) wtih CAS President Award. He obtained his PhD from University of Michigan with the support of Rackham Predoctoral Fellowship before he moved to University of Florida for his postdoc training in metabolic engineering. His lab at ASU combines genetics, experimental evolution and metabolic engineering in a concerted effort to address two great challenges in the field of applied microbiology. First, how to increase the carbon utilization efficiency of microbes when using renewable carbon sources; and second, how to optimize bacterial transport systems for bio-based production. In addition, he is also interested in altering and expanding cellular metabolisms to produce new value-added chemicals.

Education

Ph.D. Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, 2008

M.S., Biochemistry, Chinese Academy of Sciences, 2003  

B.S., Biological Science, Univ. of Sci. & Tech. of China, 2000

Google Scholar

Research Interests

Our lab aims to design and engineer recombinant microorganisms to produce valuable chemicals from renewable sources with the potential to replace petroleum-derived counterparts. Currently we are striving to characterize and overcome metabolic constraints and transport barriers that limit microbial production. Deep understanding of microbial metabolism, experimental evolution and metabolic engineering are our tools to achieve these goals.

Publications

  • Flores, A., Choi, H., Martinez, R., Onyeabor, M., Ayla EZ., Godar, A., Machas, M., Nielsen, D. and Wang X (2020) Catabolic Division of Labor Enhances Production of D-Lactate and Succinate From Glucose-Xylose Mixtures in Engineered Escherichia coli Co-culture Systems. Front Bioeng Biotechnol. 8:329. doi:10.3389/fbioe.2020.00329
  • Onyeabor, M., Martinez, R., Kurgan, G.and Wang, X. (2020) Engineering transport systems for microbial production. Adv Appl Microbiol. doi:10.1016/bs.aambs.2020.01.002
  • Kurgan, G., Kurgan, L., Schneider, A., Onyeabor, M., Rodriguez-Sanchez, Y., Taylor, E., Carbonell, P., Martinez, R., Shi, X., Gu, H. and Wang, X. (2019) Identification of major malate export systems in an engineered malate producing Escherichia coli aided by substrate similarity search. Appl Microbiol Biotechnol. doi: 10.1007/s00253-019-10164-y.
  • Martinez, R., Flores, A., Dufault, M., Wang, X. (2019) The XylR variant (R121C and P363S) releases arabinoseā€induced catabolite repression on xylose fermentation and enhances coutilization of lignocellulosic sugar mixtures. Biotechnol Bioeng. doi:10.1002/bit.27144
  • Kurgan, G., Sievert, C., Flores, A., Schneider, A., Billings, T., Panyon, L., Morris, C., Taylor, E., Kurgan, L., Cartwright, R., Wang, X. (2019) Parallel experimental evolution reveals a novel repressive control of GalP on xylose fermentation in Escherichia coli. Biotechnol Bioeng. doi:10.1002/bit.27004
  • Flores, A., Zeynep, A., Nielsen, D., Wang, X. (2019) Engineering a synthetic, catabolically orthogonal coculture system for enhanced conversion of lignocellulose-derived sugars to ethanol. ACS Synth Biol. doi:10.1021/acssynbio.9b00007
  • Flores, A., Wang, X., Nielsen, D. (2019) Recent trends in integrated bioprocesses: aiding and expanding microbial biofuel/biochemical production. Curr Opin Biotechnol. 57, 82-87
  • Kurgan, G., Panyon, L., Rodriguez-Sanchez, Y., Pacheco, E., Nieves, L. M., Mann, R., Nielsen, D., Wang, X. (2019). Bioprospecting of native efflux pumps to enhance furfural tolerance in ethanologenic Escherichia coli. Appl Environ Microbiol. 85:e02985-18
  • Machas, M., Kurgan, G., Flores, A., Schneider, A., Jha, A., Coyle, S., Varman, A., Wang, X., and Nielsen, D. (2018). Emerging tools, enabling technologies, and future opportunities for the bioproduction of aromatic chemicals. J Chem Technol Biotechnol. doi:10.1002/jctb.5762
  • Sievert, C., Nieves, L. M., Panyon, L. A., Loeffler, T., Morris, C., Cartwright, R., Wang, X. (2017) Experimental evolution reveals a novel avenue to release catabolite repression via mutations in XylR. Proc Natl Acad Sci U S A. 114, 7349-7354
  • Flores, A., Kurgan, G., Wang, X. (2016). Engineering bacterial sugar catabolism and tolerance toward lignocellulose conversion. Chapter Six in Engineering of Microorganisms for the Production of Chemicals and Biofuels from Renewable Resources. G. Gosset ed. (Springer) ISBN 9783319517285 pp. 147-180
  • Immethun, C.M., Henson, W.R., Wang, X., Nielsen, D.R. and Moon T.S. (2016). Engineering central metabolism for production of higher alcohol-based biofuels. (Book Chapter) In Biotechnologies for Biofuel Production and Optimization. C. Eckert and C. Trinh ed. (Elsevier) ISBN 9780444634757.
  • Nieves, L. M., Panyon, L. A., Wang, X. (2015) Engineering sugar utilization and microbial tolerance toward lignocellulose conversion. Front. Bioeng. Biotechnol. 3:17. doi: 10.3389/fbioe.2015.00017

Research Activity

  • SusChEM: Enhancing Tolerance and Performance of a Renewable Aromatic Biorefinery. NSF-ENG-CBET(6/15/2015 - 8/31/2019) Co-PI
  • Direct Photosynthetic Production of Biodiesel by Growth-Decoupled Cyanobacteria.DOE-BETO (09/2016-12/2018) Co-PI
  • AJINOMOTO INNOVATION ALLIANCE PROGRAM: A machine-learning algorithm to identify transporters of aromatic bioproducts for the food industry (12/2018-11/2019) PI
  • Multi-Pronged Approach to Improving Carbon Utilization by Cyanobacterial Cultures. DOE-EERE (10/1/2018-9/30/2021) Co-PI
  • CAREER: Systems-Level Identification and Characterization of Cellular Export and Efflux Systems for Renewable Chemicals. NSF-Systems and Synthetic Biology (2/1/2020-1/31/2025) PI
  • IRES: Track I: Exploring Biobased Plastics and Materials through Collaborative Research in Japan. NSF-OISE (9/1/2020-8/31/2023) Co-PI

Courses

Summer 2020
Course Number Course Title
MIC 220 Biology of Microorganisms
BIO 495 Undergraduate Research
BDE 792 Research
Spring 2020
Course Number Course Title
MIC 220 Biology of Microorganisms
MBB 493 Honors Thesis
BIO 493 Honors Thesis
MIC 495 Undergraduate Research
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
BDE 792 Research
BDE 799 Dissertation
Fall 2019
Course Number Course Title
BIO 492 Honors Directed Study
MBB 492 Honors Directed Study
MBB 494 Special Topics
BME 494 Special Topics
BIO 494 Special Topics
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
MIC 495 Undergraduate Research
MIC 501 Foundations in Microbiology
BME 598 Special Topics
BIO 598 Special Topics
MCB 598 Special Topics
Summer 2019
Course Number Course Title
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
Spring 2019
Course Number Course Title
MIC 220 Biology of Microorganisms
MBB 493 Honors Thesis
BIO 493 Honors Thesis
MIC 495 Undergraduate Research
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
BDE 792 Research
BDE 799 Dissertation
Fall 2018
Course Number Course Title
MBB 492 Honors Directed Study
BIO 492 Honors Directed Study
MBB 494 Special Topics
BCH 494 Special Topics
BME 494 Special Topics
BIO 494 Special Topics
BIO 495 Undergraduate Research
MIC 495 Undergraduate Research
MBB 495 Undergraduate Research
MCB 598 Special Topics
BCH 598 Special Topics
BME 598 Special Topics
BIO 598 Special Topics
Summer 2018
Course Number Course Title
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
BDE 792 Research
Spring 2018
Course Number Course Title
MIC 220 Biology of Microorganisms
MBB 493 Honors Thesis
MIC 495 Undergraduate Research
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
Summer 2017
Course Number Course Title
BIO 495 Undergraduate Research
Spring 2017
Course Number Course Title
MIC 220 Biology of Microorganisms
MIC 495 Undergraduate Research
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
BIO 499 Individualized Instruction
Fall 2016
Course Number Course Title
MBB 494 Special Topics
BCH 494 Special Topics
BME 494 Special Topics
BIO 494 Special Topics
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
MIC 495 Undergraduate Research
MIC 501 Foundations in Microbiology
MCB 598 Special Topics
BCH 598 Special Topics
BIO 598 Special Topics
BME 598 Special Topics
Summer 2016
Course Number Course Title
BIO 495 Undergraduate Research
Spring 2016
Course Number Course Title
MIC 220 Biology of Microorganisms
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
MIC 495 Undergraduate Research
BIO 499 Individualized Instruction
BDE 792 Research
Fall 2015
Course Number Course Title
MIC 401 Research Paper
BME 494 Special Topics
MBB 494 Special Topics
BIO 494 Special Topics
BCH 494 Special Topics
MBB 495 Undergraduate Research
MIC 495 Undergraduate Research
BIO 495 Undergraduate Research
MIC 591 Seminar
BME 598 Special Topics
BCH 598 Special Topics
BIO 598 Special Topics
MCB 598 Special Topics

Honors/Awards

  • NSF CAREER Award, 2020
  • Rackham Predoctoral Fellowship, University of Michigan, 2008
  • The President Award of Chinese Academy of Sciences, 2003

Service

  • the SCience and ENgineering Experience (SCENE) high school program (2015 - 2017)
  • 2015 Annual meeting of Society for Industrial Microbiology and Biotechnology, Conference session organizer and co-chair (2015)
  • "High School Summer Research program" organized by Ira A. Fulton Schools of Engineering, Mentor for high school students (2015 - Present)
  • Mesa Community College, Mentor for the minority undergraduates (2015 - Present)
  • SOLS Safety Committee, GEB group representative (2015 - Present)
  • ASU Open Door outreach event every year since 2015
  • Co-Director for Microbiology Graduate program (2018 - Present)
  • NSF Panelist