Xuan Wang

LSE 523
427 E. Tyler Mall
SOLS, ASU
Tempe
Assistant Professor
Faculty
TEMPE Campus
Mailcode
4501

Biography

Xuan Wang is a microbiologist who is interested in developing new microbial fermentation processes for the production of bio-based chemicals.

His lab combines genetics and metabolic engineering in a concerted effort to address two great challenges in the applied microbiology field. Those challenges include first, how to increase the efficiency of microbes to use sugars from renewable biomass; and second, how to expand cellular metabolisms to produce new “value-added” chemicals such as industrial bulk chemicals, nutrition supplements, pharmaceuticals and biological polymers.

Education

Ph.D. Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, 2008

M.S., Biochemistry, Chinese Academy of Sciences, 2003  

B.S., Biological Science, Univ. of Sci. & Tech. of China, 2000

Google Scholar

Research Interests

Our lab aims to design and construct recombinant microorganisms to produce industrial-scale valuable chemicals and materials from renewable sources to replace petroleum-based chemicals. Deep understanding of microbial metabolism and physiology, metabolic engineering and protein engineering will be the key tools to achieve our goal. We will create an collaborative environment and mark our contribution in the field of microbial technology.

Publications

Publications at ASU:

  • Martinez, R., Flores, A., Dufault, M., Wang, X. (2019) The XylR variant (R121C and P363S) releases arabinose‐induced catabolite repression on xylose fermentation and enhances coutilization of lignocellulosic sugar mixtures. Biotechnol Bioeng. doi:10.1002/bit.27144
  • Kurgan, G., Sievert, C., Flores, A., Schneider, A., Billings, T., Panyon, L., Morris, C., Taylor, E., Kurgan, L., Cartwright, R., Wang, X. (2019) Parallel experimental evolution reveals a novel repressive control of GalP on xylose fermentation in Escherichia coli. Biotechnol Bioeng. doi:10.1002/bit.27004
  • Flores, A., Zeynep, A., Nielsen, D., Wang, X. (2019) Engineering a synthetic, catabolically orthogonal coculture system for enhanced conversion of lignocellulose-derived sugars to ethanol. ACS Synth Biol. doi:10.1021/acssynbio.9b00007
  • Flores, A., Wang, X., Nielsen, D. (2019) Recent trends in integrated bioprocesses: aiding and expanding microbial biofuel/biochemical production. Curr Opin Biotechnol. 57, 82-87
  • Kurgan, G., Panyon, L., Rodriguez-Sanchez, Y., Pacheco, E., Nieves, L. M., Mann, R., Nielsen, D., Wang, X. (2019). Bioprospecting of native efflux pumps to enhance furfural tolerance in ethanologenic Escherichia coli. Appl Environ Microbiol. 85:e02985-18
  • Machas, M., Kurgan, G., Flores, A., Schneider, A., Jha, A., Coyle, S., Varman, A., Wang, X., and Nielsen, D. (2018). Emerging tools, enabling technologies, and future opportunities for the bioproduction of aromatic chemicals. J Chem Technol Biotechnol. doi:10.1002/jctb.5762
  • Sievert, C., Nieves, L. M., Panyon, L. A., Loeffler, T., Morris, C., Cartwright, R., Wang, X. (2017) Experimental evolution reveals a novel avenue to release catabolite repression via mutations in XylR. Proc Natl Acad Sci U S A. 114, 7349-7354
  • Flores, A., Kurgan, G., Wang, X. (2016). Engineering bacterial sugar catabolism and tolerance toward lignocellulose conversion. Chapter Six in Engineering of Microorganisms for the Production of Chemicals and Biofuels from Renewable Resources. G. Gosset ed. (Springer) ISBN 9783319517285 pp. 147-180
  • Immethun, C.M., Henson, W.R., Wang, X., Nielsen, D.R. and Moon T.S. (2016). Engineering central metabolism for production of higher alcohol-based biofuels. Chapter One in Biotechnologies for Biofuel Production and Optimization. C. Eckert and C. Trinh ed. (Elsevier) ISBN 9780444634757 pp. 1-34
  • Nieves, L. M., Panyon, L. A., Wang, X. (2015) Engineering sugar utilization and microbial tolerance toward lignocellulose conversion. Front. Bioeng. Biotechnol. 3:17. doi: 10.3389/fbioe.2015.00017
  • Geddes, R. D., Wang, X., Yomano, L. P., Miller, E. N., Zheng, H., Shanmugam, K. T., Ingram, L. O. (2014). Polyamine transporters and polyamines increase furfural tolerance during xylose ermentation with ethanologenic Escherichia coli strain LY180. Appl Environ Microbiol. 80, 5955-5964

Representative publications prior to ASU:

  • Wang, X., Yomano, L.P., Lee, J.Y., Sean, S.Y., Zheng, H., Mullinnix, M.T., Shanmugam K. T., Ingram, L.O. (2013) Engineering furfural tolerance in Escherichia coli improves the fermentation of lignocellulosic sugars into renewable chemicals. Proc Natl Acad Sci U S A. 110, 4021-4026
  • Wang, X., Miller, E.N., Yomano, L.P., Shanmugam K. T., Ingram, L.O. (2012) Increased furan tolerance in Escherichia coli due to a cryptic ucpA gene. Appl Environ Microbiol. 78, 2452-2455
  • Wang, X.*, Miller, E.N.*, Yomano, L.P., Zhang, X. Shanmugam K. T., Ingram, L.O. (2011) Increased furfural tolerance due to overexpression of NADH-dependent oxidoreductase FucO in Escherichia coli strains engineered for the production of ethanoland lactate. Appl Environ Microbiol. 77, 5132-5140 *Equally contributed.
  • Zhang, X. *, Wang, X. *, Shanmugam K. T., Ingram, L.O. (2011).L-Malate production by metabolically engineered Escherichia coli.Appl Environ Microbiol. 77, 427-434 *Equally contributed.
  • Wang, X., Zhou, Y., Ren, J., Hammer, N. D. and Chapman, M. R. (2010). Gatekeeper residues in major curlin subunit modulate bacterial amyloid fiber biogenesis. Proc Natl Acad Sci U S A. 107, 163-168
  • Wang, X. and Chapman, M. R. (2010). Functional microbial amyloids: protein misfolding done right. In Functional Amyloid Aggregation, S. Rigacci and M. Bucciantini, ed. (ISBN: 978-81-308-0425-5) pp. 21-35
  • Wang, X. and Chapman, M. R. (2008). Curli provide the template for understanding controlled amyloid propagation. Prion. 2, 57-60
  • Wang, X. and Chapman, M. R. (2008). Sequence determinants of bacterial amyloid formation. J Mol Biol. 380, 570-580
  • Wang, X., Hammer, N. D. and Chapman, M. R. (2008). The molecular basis of bacterial amyloid polymerization and nucleation. J Biol Chem. 283, 21530-21539 *Selected by Faculty of 1000 Biology
  • Wang, X., Smith, D. R., Jones, J. W., and Chapman, M. R. (2007). In vitro polymerization of a functional Escherichia coli amyloid protein. J Biol Chem. 282, 3713-3719

Research Activity

  • SusChEM: Enhancing Tolerance and Performance of a Renewable Aromatic Biorefinery. NSF-ENG-CBET(6/15/2015 - 8/31/2019).
  • Direct Photosynthetic Production of Biodiesel by Growth-Decoupled Cyanobacteria.DOE-BETO (09/2016-12/2018)
  • Multi-pronged approach to improving carbon utilization by cyanobacterial cultures. DOE-EERE (10/1/2018-9/30/2021)

Courses

Fall 2019
Course Number Course Title
BIO 492 Honors Directed Study
MBB 492 Honors Directed Study
MBB 494 Special Topics
BME 494 Special Topics
BIO 494 Special Topics
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
MIC 495 Undergraduate Research
MIC 501 Foundations in Microbiology
BME 598 Special Topics
BIO 598 Special Topics
MCB 598 Special Topics
Summer 2019
Course Number Course Title
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
Spring 2019
Course Number Course Title
MIC 220 Biology of Microorganisms
MBB 493 Honors Thesis
BIO 493 Honors Thesis
MIC 495 Undergraduate Research
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
BDE 792 Research
BDE 799 Dissertation
Fall 2018
Course Number Course Title
MBB 492 Honors Directed Study
BIO 492 Honors Directed Study
MBB 494 Special Topics
BCH 494 Special Topics
BME 494 Special Topics
BIO 494 Special Topics
BIO 495 Undergraduate Research
MIC 495 Undergraduate Research
MBB 495 Undergraduate Research
MCB 598 Special Topics
BCH 598 Special Topics
BME 598 Special Topics
BIO 598 Special Topics
Summer 2018
Course Number Course Title
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
BDE 792 Research
Spring 2018
Course Number Course Title
MIC 220 Biology of Microorganisms
MBB 493 Honors Thesis
MIC 495 Undergraduate Research
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
Summer 2017
Course Number Course Title
BIO 495 Undergraduate Research
Spring 2017
Course Number Course Title
MIC 220 Biology of Microorganisms
MIC 495 Undergraduate Research
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
BIO 499 Individualized Instruction
Fall 2016
Course Number Course Title
MBB 494 Special Topics
BCH 494 Special Topics
BME 494 Special Topics
BIO 494 Special Topics
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
MIC 495 Undergraduate Research
MIC 501 Foundations in Microbiology
MCB 598 Special Topics
BCH 598 Special Topics
BIO 598 Special Topics
BME 598 Special Topics
Summer 2016
Course Number Course Title
BIO 495 Undergraduate Research
Spring 2016
Course Number Course Title
MIC 220 Biology of Microorganisms
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
MIC 495 Undergraduate Research
BIO 499 Individualized Instruction
BDE 792 Research
Fall 2015
Course Number Course Title
MIC 401 Research Paper
BME 494 Special Topics
MBB 494 Special Topics
BIO 494 Special Topics
BCH 494 Special Topics
MBB 495 Undergraduate Research
MIC 495 Undergraduate Research
BIO 495 Undergraduate Research
MIC 591 Seminar
BME 598 Special Topics
BCH 598 Special Topics
BIO 598 Special Topics
MCB 598 Special Topics
Summer 2015
Course Number Course Title
BIO 495 Undergraduate Research
Spring 2015
Course Number Course Title
MIC 401 Research Paper
MIC 495 Undergraduate Research
MBB 495 Undergraduate Research
BIO 495 Undergraduate Research
BIO 499 Individualized Instruction

Service

  • the SCience and ENgineering Experience (SCENE) high school program (2015 - Present)
  • 2015 Annual meeting of Society for Industrial Microbiology and Biotechnology, Conference session organizer and co-chair (2015)
  • "High School Summer Research program" organized by Ira A. Fulton Schools of Engineering, Mentor for high school students (2015 - Present)
  • Mesa Community College, Mentor for the minority undergraduates (2015 - Present)
  • SOLS Safety Committee, GEB group representative (2015 - Present)
  • ASU Open Door outreach event every year since 2015